Inhibition of Endothelial–Mesenchymal Transition Mediated by Activin Receptor Type IIA Attenuates Valvular Injury Induced by Group A Streptococcus in Lewis Rats

Inhibition of Endothelial–Mesenchymal Transition Mediated by Activin Receptor Type IIA Attenuates Valvular Injury Induced by Group A Streptococcus in Lewis Rats

Background: Rheumatic heart disease (RHD), which is caused mainly by Group A Streptococcus, leads to fibrotic damage to heart valves. Recently, endothelial‒mesenchymal transition (EndMT), in which activin plays an important role, has been shown to be an important factor in RHD val...

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Bibliographic Details
Main Authors: Zirong Lu, Yuan Li, Chuanghong Lu, Zhongyuan Meng, Ling Bai, Feng Huang, Zhiyu Zeng
Format: Article
Language:English
Published: IMR Press 2025-01-01
Series:Frontiers in Bioscience-Landmark
Subjects:
activin
acvr2a
rheumatic heart disease
endothelial–mesenchymal transition
valvular injury
Online Access:https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL26370
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