Possible Protective Effects of Saw Palmetto Extract in Indomethacin Treated Rats
Background: Indomethacin is a widely used nonsteroidal anti-inflammatory drug for treating pain and fever. It is coupled with oxidative stress and an inflammatory response, which accounts for several detrimental effects on the body’s organs. Objectives: This study aimed to assess the potential of...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
College of Medicine University of Baghdad
2025-04-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | https://www.iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2474 |
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| Summary: | Background: Indomethacin is a widely used nonsteroidal anti-inflammatory drug for treating pain and fever. It is coupled with oxidative stress and an inflammatory response, which accounts for several detrimental effects on the body’s organs.
Objectives: This study aimed to assess the potential of using SSaw palmetto extract to counteract the oxidative stress and inflammatory response resulting from Indomethacin treatment in rat models.
Methods: The study involved 20 male albino rats, arbitrarily sorted into four groups of 5 animals each group. Group 1 (control group) was neither induced nor treated. Groups (2-4) were treated with oral Omeprazole (20 mg/kg/day) and Saw palmetto extract (20 mg/kg/day) suspensions, respectively, for 15 days. On day 15 of the study, blood samples were taken by heart puncture for the determination of superoxide dismutase, glutathione peroxidase, tumor necrosis factor-alpha, and interleukin-6.
Results: Saw palmetto extract treatment was found to elevate serum levels of superoxide dismutase and glutathione peroxidase significantly compared to the Indomethacin-induction group. Conversely, tumor necrosis factor-alpha and interleukin-6 levels were markedly reduced compared to the Indomethacin-induction group. The antioxidant and anti-inflammatory activities of Saw palmetto extract are contingent on its bioactive flavonoids and sitosterols content.
Conclusion: The antioxidant and anti-inflammatory influence of Saw palmetto extract could be a promising approach to counteract oxidative stress and inflammatory response due to Indomethacin treatment.
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| ISSN: | 0041-9419 2410-8057 |