The Use of Liver Support System Devices in Acute Liver Failure as a Consequence of Metastatic Melanoma in the Liver: A Case Report and Review of the Literature
Introduction: Melanoma often metastasizes to the liver, leading to significant morbidity and mortality. Liver injury can also occur due to hepatitis caused by immunotherapy used in the treatment of melanoma. Case Presentation: This case report presents a 38-year-old male diagnosed...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2024-12-01
|
| Series: | Case Reports in Oncology |
| Online Access: | https://karger.com/article/doi/10.1159/000541419 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850274857322807296 |
|---|---|
| author | Anamarija Bukovica Petrc Tihana Salopek Iva Skočilić Dag Zahirovic Lidija Orlic Ivan Bubic Zrinka Matana-Kastelan Sara Francetic Karla Lisica Ivana Mikolasevic |
| author_facet | Anamarija Bukovica Petrc Tihana Salopek Iva Skočilić Dag Zahirovic Lidija Orlic Ivan Bubic Zrinka Matana-Kastelan Sara Francetic Karla Lisica Ivana Mikolasevic |
| author_sort | Anamarija Bukovica Petrc |
| collection | DOAJ |
| description |
Introduction:
Melanoma often metastasizes to the liver, leading to significant morbidity and mortality. Liver injury can also occur due to hepatitis caused by immunotherapy used in the treatment of melanoma.
Case Presentation:
This case report presents a 38-year-old male diagnosed with advanced melanoma who experienced acute liver failure (ALF) initially thought to be a side effect of immunotherapy. Despite following aggressive supportive care as per the latest guidelines, the patient’s condition deteriorated rapidly. It was discovered that the patient had liver metastases. As the tumor had a positive BRAF mutation, we opted for invasive treatment with therapeutic plasma exchange to restore liver function and create the conditions for initiating treatment with BRAF/MEK inhibitors. After the use of a liver support device, the liver function was resolved, and a BRAF/MEK inhibitor was introduced. After 2 months of targeted therapy, a favorable effect and good melanoma control are observed.
Conclusion:
The report underscores the complexity of managing melanoma with liver metastasis and the urgent need for advancements in treatment modalities ALF in oncology patients. We suggest that invasive treatment methods, such as liver support system devices, should be considered in well-selected oncology patients, even in advanced stages of disease. |
| format | Article |
| id | doaj-art-a0fb8bcf7e4b468da1cb30f515e02a80 |
| institution | OA Journals |
| issn | 1662-6575 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj-art-a0fb8bcf7e4b468da1cb30f515e02a802025-08-20T01:51:02ZengKarger PublishersCase Reports in Oncology1662-65752024-12-0118171410.1159/000541419The Use of Liver Support System Devices in Acute Liver Failure as a Consequence of Metastatic Melanoma in the Liver: A Case Report and Review of the LiteratureAnamarija Bukovica PetrcTihana SalopekIva SkočilićDag ZahirovicLidija OrlicIvan BubicZrinka Matana-KastelanSara FranceticKarla LisicaIvana Mikolasevic Introduction: Melanoma often metastasizes to the liver, leading to significant morbidity and mortality. Liver injury can also occur due to hepatitis caused by immunotherapy used in the treatment of melanoma. Case Presentation: This case report presents a 38-year-old male diagnosed with advanced melanoma who experienced acute liver failure (ALF) initially thought to be a side effect of immunotherapy. Despite following aggressive supportive care as per the latest guidelines, the patient’s condition deteriorated rapidly. It was discovered that the patient had liver metastases. As the tumor had a positive BRAF mutation, we opted for invasive treatment with therapeutic plasma exchange to restore liver function and create the conditions for initiating treatment with BRAF/MEK inhibitors. After the use of a liver support device, the liver function was resolved, and a BRAF/MEK inhibitor was introduced. After 2 months of targeted therapy, a favorable effect and good melanoma control are observed. Conclusion: The report underscores the complexity of managing melanoma with liver metastasis and the urgent need for advancements in treatment modalities ALF in oncology patients. We suggest that invasive treatment methods, such as liver support system devices, should be considered in well-selected oncology patients, even in advanced stages of disease.https://karger.com/article/doi/10.1159/000541419 |
| spellingShingle | Anamarija Bukovica Petrc Tihana Salopek Iva Skočilić Dag Zahirovic Lidija Orlic Ivan Bubic Zrinka Matana-Kastelan Sara Francetic Karla Lisica Ivana Mikolasevic The Use of Liver Support System Devices in Acute Liver Failure as a Consequence of Metastatic Melanoma in the Liver: A Case Report and Review of the Literature Case Reports in Oncology |
| title | The Use of Liver Support System Devices in Acute Liver Failure as a Consequence of Metastatic Melanoma in the Liver: A Case Report and Review of the Literature |
| title_full | The Use of Liver Support System Devices in Acute Liver Failure as a Consequence of Metastatic Melanoma in the Liver: A Case Report and Review of the Literature |
| title_fullStr | The Use of Liver Support System Devices in Acute Liver Failure as a Consequence of Metastatic Melanoma in the Liver: A Case Report and Review of the Literature |
| title_full_unstemmed | The Use of Liver Support System Devices in Acute Liver Failure as a Consequence of Metastatic Melanoma in the Liver: A Case Report and Review of the Literature |
| title_short | The Use of Liver Support System Devices in Acute Liver Failure as a Consequence of Metastatic Melanoma in the Liver: A Case Report and Review of the Literature |
| title_sort | use of liver support system devices in acute liver failure as a consequence of metastatic melanoma in the liver a case report and review of the literature |
| url | https://karger.com/article/doi/10.1159/000541419 |
| work_keys_str_mv | AT anamarijabukovicapetrc theuseofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT tihanasalopek theuseofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT ivaskocilic theuseofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT dagzahirovic theuseofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT lidijaorlic theuseofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT ivanbubic theuseofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT zrinkamatanakastelan theuseofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT sarafrancetic theuseofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT karlalisica theuseofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT ivanamikolasevic theuseofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT anamarijabukovicapetrc useofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT tihanasalopek useofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT ivaskocilic useofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT dagzahirovic useofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT lidijaorlic useofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT ivanbubic useofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT zrinkamatanakastelan useofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT sarafrancetic useofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT karlalisica useofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature AT ivanamikolasevic useofliversupportsystemdevicesinacuteliverfailureasaconsequenceofmetastaticmelanomaintheliveracasereportandreviewoftheliterature |