Pneumothorax during Alectinib Treatment for a Uterine Inflammatory Myofibroblastic Tumor with Lung Metastasis
An inflammatory myofibroblastic tumor (IMT) is an uncommon sarcoma subtype with histopathological features, including inflammatory infiltrates. Anaplastic lymphoma kinase (ALK) gene rearrangement has been reported in half of the patients with IMTs; therefore, crizotinib, an ALK inhibitor, may achiev...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-04-01
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| Series: | Journal of Cancer Research and Practice |
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| Online Access: | https://journals.lww.com/10.4103/ejcrp.eJCRP-D-22-00031 |
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| author | Chang-Ting Lin Chen-Hsuan Wu Hsuan-Ying Huang Chien-Ting Liu |
| author_facet | Chang-Ting Lin Chen-Hsuan Wu Hsuan-Ying Huang Chien-Ting Liu |
| author_sort | Chang-Ting Lin |
| collection | DOAJ |
| description | An inflammatory myofibroblastic tumor (IMT) is an uncommon sarcoma subtype with histopathological features, including inflammatory infiltrates. Anaplastic lymphoma kinase (ALK) gene rearrangement has been reported in half of the patients with IMTs; therefore, crizotinib, an ALK inhibitor, may achieve a response rate of 50% in these patients. We present a case with an initial diagnosis of uterine sarcoma and multiple lung metastases. After the failure of doxorubicin-based chemotherapy, revised pathology from a palliative hysterectomy revealed an IMT with ALK gene rearrangement. Treatment with alectinib achieved an excellent tumor response. The accurate differential diagnosis of uncommon sarcoma subtypes is crucial because a specific targeted therapy may considerably alter treatment outcomes. |
| format | Article |
| id | doaj-art-a0e07ce0c9d94afba339fe1bbf7cf4d9 |
| institution | Kabale University |
| issn | 2311-3006 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Cancer Research and Practice |
| spelling | doaj-art-a0e07ce0c9d94afba339fe1bbf7cf4d92025-01-23T05:04:56ZengWolters Kluwer Medknow PublicationsJournal of Cancer Research and Practice2311-30062023-04-01102717410.4103/ejcrp.eJCRP-D-22-00031Pneumothorax during Alectinib Treatment for a Uterine Inflammatory Myofibroblastic Tumor with Lung MetastasisChang-Ting LinChen-Hsuan WuHsuan-Ying HuangChien-Ting LiuAn inflammatory myofibroblastic tumor (IMT) is an uncommon sarcoma subtype with histopathological features, including inflammatory infiltrates. Anaplastic lymphoma kinase (ALK) gene rearrangement has been reported in half of the patients with IMTs; therefore, crizotinib, an ALK inhibitor, may achieve a response rate of 50% in these patients. We present a case with an initial diagnosis of uterine sarcoma and multiple lung metastases. After the failure of doxorubicin-based chemotherapy, revised pathology from a palliative hysterectomy revealed an IMT with ALK gene rearrangement. Treatment with alectinib achieved an excellent tumor response. The accurate differential diagnosis of uncommon sarcoma subtypes is crucial because a specific targeted therapy may considerably alter treatment outcomes.https://journals.lww.com/10.4103/ejcrp.eJCRP-D-22-00031alectinibinflammatory myofibroblastic tumorpneumothorax |
| spellingShingle | Chang-Ting Lin Chen-Hsuan Wu Hsuan-Ying Huang Chien-Ting Liu Pneumothorax during Alectinib Treatment for a Uterine Inflammatory Myofibroblastic Tumor with Lung Metastasis Journal of Cancer Research and Practice alectinib inflammatory myofibroblastic tumor pneumothorax |
| title | Pneumothorax during Alectinib Treatment for a Uterine Inflammatory Myofibroblastic Tumor with Lung Metastasis |
| title_full | Pneumothorax during Alectinib Treatment for a Uterine Inflammatory Myofibroblastic Tumor with Lung Metastasis |
| title_fullStr | Pneumothorax during Alectinib Treatment for a Uterine Inflammatory Myofibroblastic Tumor with Lung Metastasis |
| title_full_unstemmed | Pneumothorax during Alectinib Treatment for a Uterine Inflammatory Myofibroblastic Tumor with Lung Metastasis |
| title_short | Pneumothorax during Alectinib Treatment for a Uterine Inflammatory Myofibroblastic Tumor with Lung Metastasis |
| title_sort | pneumothorax during alectinib treatment for a uterine inflammatory myofibroblastic tumor with lung metastasis |
| topic | alectinib inflammatory myofibroblastic tumor pneumothorax |
| url | https://journals.lww.com/10.4103/ejcrp.eJCRP-D-22-00031 |
| work_keys_str_mv | AT changtinglin pneumothoraxduringalectinibtreatmentforauterineinflammatorymyofibroblastictumorwithlungmetastasis AT chenhsuanwu pneumothoraxduringalectinibtreatmentforauterineinflammatorymyofibroblastictumorwithlungmetastasis AT hsuanyinghuang pneumothoraxduringalectinibtreatmentforauterineinflammatorymyofibroblastictumorwithlungmetastasis AT chientingliu pneumothoraxduringalectinibtreatmentforauterineinflammatorymyofibroblastictumorwithlungmetastasis |