Uncovering key regulatory pathways and prognostic biomarkers in the tumor microenvironment of high-grade serous ovarian cancer through single-cell RNA sequencing and experimental validation

Uncovering key regulatory pathways and prognostic biomarkers in the tumor microenvironment of high-grade serous ovarian cancer through single-cell RNA sequencing and experimental validation

BackgroundHigh-grade serous ovarian cancer (HGSOC) is a leading cause of cancer-related deaths among women globally. This study aims to identify novel regulatory targets and signaling pathways that modulate the tumor microenvironment (TME) in HGSOC, focusing on the pleiotrophin (PTN) signaling pathw...

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Bibliographic Details
Main Authors: Yue Li, Long Zhao, Ying Tian, Qianqian Zhou, Xia Liu, Shucai Yang, Jinfeng Xu, Chang Zou, Jinling Zhang, Hui Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
high-grade serous ovarian cancer (HGSOC)
tumor microenvironment (TME)
pleiotrophin (PTN) signaling
syndecan 4 (SDC4)
single-cell RNA sequencing (scRNA-seq)
experimental validation
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1591430/full
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