A Case of Low-Grade Oncocytic Tumor/Chromophobe Renal Cell Carcinoma (Oncocytic Variant) of the Kidney
The oncocytic variant of chromophobe renal cell carcinoma (oChRCC) and low-grade oncocytic tumor (LOT) is introduced as new renal disease entity. Both of these tumors are low-grade malignancies consisting of cells with eosinophilic cytoplasm. Distinguishing between eosinophilic variant of chromophob...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2021/6684777 |
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| author | Noriyoshi Ishikawa Nao Kimura Toshio Yoshida Ichiro Yoshimura Ken Nakahara Toyonori Tsuzuki Osamu Tokunaga |
| author_facet | Noriyoshi Ishikawa Nao Kimura Toshio Yoshida Ichiro Yoshimura Ken Nakahara Toyonori Tsuzuki Osamu Tokunaga |
| author_sort | Noriyoshi Ishikawa |
| collection | DOAJ |
| description | The oncocytic variant of chromophobe renal cell carcinoma (oChRCC) and low-grade oncocytic tumor (LOT) is introduced as new renal disease entity. Both of these tumors are low-grade malignancies consisting of cells with eosinophilic cytoplasm. Distinguishing between eosinophilic variant of chromophobe renal cell carcinoma (eCRCC) and oncocytoma is often a diagnostic challenge in routine surgical pathology. However, oChRCC and LOT might be independent disease entities that might not fit completely into any of these categories. Histologically, these tumors have greater morphological similarity with oncocytoma than with ChRCC. However, immunohistochemically, they exhibit diffuse and dense positivity for CK7 and are negative for CD117. In the present case, we initially had difficulty distinguishing among oncocytoma, eCRCC, and type 2 papillary renal cell carcinoma (2-pRCC). However, after learning about new disease entities such as oChRCC and LOT, we were able to diagnose this tumor. |
| format | Article |
| id | doaj-art-a0d9e13c3bd844eea86618fc7605ed4c |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-a0d9e13c3bd844eea86618fc7605ed4c2025-02-03T00:58:59ZengWileyCase Reports in Pathology2090-67812090-679X2021-01-01202110.1155/2021/66847776684777A Case of Low-Grade Oncocytic Tumor/Chromophobe Renal Cell Carcinoma (Oncocytic Variant) of the KidneyNoriyoshi Ishikawa0Nao Kimura1Toshio Yoshida2Ichiro Yoshimura3Ken Nakahara4Toyonori Tsuzuki5Osamu Tokunaga6Department of Pathology, Shonan Fujisawa Tokushukai Hospital, 1-5-1 Tsujido-kandai, Fujisawa, Kanagawa 251-0041, JapanDepartment of Pathology, Shonan Fujisawa Tokushukai Hospital, 1-5-1 Tsujido-kandai, Fujisawa, Kanagawa 251-0041, JapanDepartment of Urology, Shonan Fujisawa Tokushukai Hospital, JapanDepartment of Urology, Shonan Fujisawa Tokushukai Hospital, JapanDepartment of Urology, Shonan Fujisawa Tokushukai Hospital, JapanDepartment of Surgical Pathology, Aichi Medical University, School of Medicine, JapanDepartment of Pathology, Shonan Fujisawa Tokushukai Hospital, 1-5-1 Tsujido-kandai, Fujisawa, Kanagawa 251-0041, JapanThe oncocytic variant of chromophobe renal cell carcinoma (oChRCC) and low-grade oncocytic tumor (LOT) is introduced as new renal disease entity. Both of these tumors are low-grade malignancies consisting of cells with eosinophilic cytoplasm. Distinguishing between eosinophilic variant of chromophobe renal cell carcinoma (eCRCC) and oncocytoma is often a diagnostic challenge in routine surgical pathology. However, oChRCC and LOT might be independent disease entities that might not fit completely into any of these categories. Histologically, these tumors have greater morphological similarity with oncocytoma than with ChRCC. However, immunohistochemically, they exhibit diffuse and dense positivity for CK7 and are negative for CD117. In the present case, we initially had difficulty distinguishing among oncocytoma, eCRCC, and type 2 papillary renal cell carcinoma (2-pRCC). However, after learning about new disease entities such as oChRCC and LOT, we were able to diagnose this tumor.http://dx.doi.org/10.1155/2021/6684777 |
| spellingShingle | Noriyoshi Ishikawa Nao Kimura Toshio Yoshida Ichiro Yoshimura Ken Nakahara Toyonori Tsuzuki Osamu Tokunaga A Case of Low-Grade Oncocytic Tumor/Chromophobe Renal Cell Carcinoma (Oncocytic Variant) of the Kidney Case Reports in Pathology |
| title | A Case of Low-Grade Oncocytic Tumor/Chromophobe Renal Cell Carcinoma (Oncocytic Variant) of the Kidney |
| title_full | A Case of Low-Grade Oncocytic Tumor/Chromophobe Renal Cell Carcinoma (Oncocytic Variant) of the Kidney |
| title_fullStr | A Case of Low-Grade Oncocytic Tumor/Chromophobe Renal Cell Carcinoma (Oncocytic Variant) of the Kidney |
| title_full_unstemmed | A Case of Low-Grade Oncocytic Tumor/Chromophobe Renal Cell Carcinoma (Oncocytic Variant) of the Kidney |
| title_short | A Case of Low-Grade Oncocytic Tumor/Chromophobe Renal Cell Carcinoma (Oncocytic Variant) of the Kidney |
| title_sort | case of low grade oncocytic tumor chromophobe renal cell carcinoma oncocytic variant of the kidney |
| url | http://dx.doi.org/10.1155/2021/6684777 |
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