Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer

Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer

Abstract Background Radiotherapy is the primary treatment modality for most head and neck cancers (HNCs). Despite the addition of chemotherapy to radiotherapy to enhance its tumoricidal effects, almost a third of HNC patients suffer from locoregional relapses. Salvage therapy options for such recurr...

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Main Authors: Sharon Pei Yi Chan, Celestia Pei Xuan Yeo, Boon Hao Hong, Evelyn Mui Cheng Tan, Chaw Yee Beh, Eugenia Li Ling Yeo, Dennis Jun Jie Poon, Pek Lim Chu, Khee Chee Soo, Melvin Lee Kiang Chua, Edward Kai-Hua Chow
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Experimental Hematology & Oncology
Subjects:
Head and neck cancer
Radioresistance
Combination therapy
HDAC6 inhibition
Online Access:https://doi.org/10.1186/s40164-024-00590-8
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