The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases

The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases

Phosphatidic acid phosphatase (PAP) is an evolutionarily conserved eukaryotic enzyme that catalyzes the Mg2+-dependent dephosphorylation of phosphatidic acid to produce diacylglycerol. The product and substrate of PAP are key intermediates in the synthesis of triacylglycerol and membrane phospholipi...

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Bibliographic Details
Main Authors: Geordan J. Stukey, Matthew R. Breuer, Natalie Burchat, Ruta Jog, Kollin Schultz, Gil-Soo Han, Matthew S. Sachs, Harini Sampath, Ronen Marmorstein, George M. Carman
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Journal of Lipid Research
Subjects:
phosphatidic acid phosphatase
Pah1
lipin 1
diacylglycerol
triacylglycerol
sertraline
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227524002165
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