Thromboembolic Events Secondary to Endoscopic Cyanoacrylate Injection: Can We Foresee Any Red Flags?
Background. Gastric varices (GV) are associated with high morbidity and mortality in patients with portal hypertension. Endoscopic cyanoacrylate injection is the first-line recommended therapy for GV obliteration. This study aims to explore the reason behind related adverse events and better prevent...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2018/1940592 |
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| author | Yujen Tseng Lili Ma Tiancheng Luo Xiaoqing Zeng Yichao Wei Ling Li Pengju Xu Shiyao Chen |
| author_facet | Yujen Tseng Lili Ma Tiancheng Luo Xiaoqing Zeng Yichao Wei Ling Li Pengju Xu Shiyao Chen |
| author_sort | Yujen Tseng |
| collection | DOAJ |
| description | Background. Gastric varices (GV) are associated with high morbidity and mortality in patients with portal hypertension. Endoscopic cyanoacrylate injection is the first-line recommended therapy for GV obliteration. This study aims to explore the reason behind related adverse events and better prevent its occurrence. Methods. A retrospective case series study was conducted from January 1, 2013, to December 31, 2016, to identify patients who experienced severe adverse events secondary to endoscopic cyanoacrylate injection. A literature review of similar cases was performed on two medical databases, Medline and Embase. Results. A total of 652 patients underwent cyanoacrylate injection at our center within the study duration. Five cases of severe adverse events related to the use of tissue adhesives were identified. Detailed clinical presentation, patient treatment, and outcomes were reviewed and analyzed. Twenty-seven similar cases were identified based on the literature review providing further insight into the study. Conclusion. Although rare in incidence, systemic embolism associated with cyanoacrylate injection is often fatal or debilitating. This report may raise awareness in treatment protocol, including the necessity of preoperative angiographic studies, to avoid similar adverse events in clinical practice. |
| format | Article |
| id | doaj-art-a0cfa6e6d6a8498a8f3772c066453519 |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-a0cfa6e6d6a8498a8f3772c0664535192025-02-03T05:43:43ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972018-01-01201810.1155/2018/19405921940592Thromboembolic Events Secondary to Endoscopic Cyanoacrylate Injection: Can We Foresee Any Red Flags?Yujen Tseng0Lili Ma1Tiancheng Luo2Xiaoqing Zeng3Yichao Wei4Ling Li5Pengju Xu6Shiyao Chen7Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Endoscopy Center, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Gastroenterology, Endoscopy Center and Evidence-Based Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, ChinaBackground. Gastric varices (GV) are associated with high morbidity and mortality in patients with portal hypertension. Endoscopic cyanoacrylate injection is the first-line recommended therapy for GV obliteration. This study aims to explore the reason behind related adverse events and better prevent its occurrence. Methods. A retrospective case series study was conducted from January 1, 2013, to December 31, 2016, to identify patients who experienced severe adverse events secondary to endoscopic cyanoacrylate injection. A literature review of similar cases was performed on two medical databases, Medline and Embase. Results. A total of 652 patients underwent cyanoacrylate injection at our center within the study duration. Five cases of severe adverse events related to the use of tissue adhesives were identified. Detailed clinical presentation, patient treatment, and outcomes were reviewed and analyzed. Twenty-seven similar cases were identified based on the literature review providing further insight into the study. Conclusion. Although rare in incidence, systemic embolism associated with cyanoacrylate injection is often fatal or debilitating. This report may raise awareness in treatment protocol, including the necessity of preoperative angiographic studies, to avoid similar adverse events in clinical practice.http://dx.doi.org/10.1155/2018/1940592 |
| spellingShingle | Yujen Tseng Lili Ma Tiancheng Luo Xiaoqing Zeng Yichao Wei Ling Li Pengju Xu Shiyao Chen Thromboembolic Events Secondary to Endoscopic Cyanoacrylate Injection: Can We Foresee Any Red Flags? Canadian Journal of Gastroenterology and Hepatology |
| title | Thromboembolic Events Secondary to Endoscopic Cyanoacrylate Injection: Can We Foresee Any Red Flags? |
| title_full | Thromboembolic Events Secondary to Endoscopic Cyanoacrylate Injection: Can We Foresee Any Red Flags? |
| title_fullStr | Thromboembolic Events Secondary to Endoscopic Cyanoacrylate Injection: Can We Foresee Any Red Flags? |
| title_full_unstemmed | Thromboembolic Events Secondary to Endoscopic Cyanoacrylate Injection: Can We Foresee Any Red Flags? |
| title_short | Thromboembolic Events Secondary to Endoscopic Cyanoacrylate Injection: Can We Foresee Any Red Flags? |
| title_sort | thromboembolic events secondary to endoscopic cyanoacrylate injection can we foresee any red flags |
| url | http://dx.doi.org/10.1155/2018/1940592 |
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