Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component
Large cell neuroendocrine carcinoma (LCNC) is one of the rarest types of bladder cancer occurring in <1%. Either pure or mixed with another component, it remains one of the most aggressive types of bladder cancer. We report a case of LCNC of the bladder with an adenocarcinomatous component. The p...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2020/8827646 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566496391331840 |
|---|---|
| author | Rami Halabi Maher Abdessater Johnny Boustany Anthony Kanbar Halim Akl Joey El Khoury Charbel El Hachem Raghid El Khoury |
| author_facet | Rami Halabi Maher Abdessater Johnny Boustany Anthony Kanbar Halim Akl Joey El Khoury Charbel El Hachem Raghid El Khoury |
| author_sort | Rami Halabi |
| collection | DOAJ |
| description | Large cell neuroendocrine carcinoma (LCNC) is one of the rarest types of bladder cancer occurring in <1%. Either pure or mixed with another component, it remains one of the most aggressive types of bladder cancer. We report a case of LCNC of the bladder with an adenocarcinomatous component. The patient was a 64-year-old smoker male, who presented for the first time with dysuria and hematuria. A bladder tumor invading the anterior and right lateral bladder walls was discovered, without any secondary localizations. Tumor biopsy showed an LCNC with adenocarcinomatous components. The patient was treated by recurrent tumor resections, chemotherapy, and radiotherapy. No improvement was noted despite close follow-up and adequate treatment. Neuroendocrine bladder tumor is known to have an aggressive, rapid, and disadvantageous evolution. Multiple case reports were published so far, and a recent review was conducted in March 2020 by Sanguedolce et al. (2020). More cases are needed to establish the best management plan for this type of tumor. |
| format | Article |
| id | doaj-art-a0c71cdeda1a4da98fb970c18bfbdaec |
| institution | Kabale University |
| issn | 2090-696X 2090-6978 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-a0c71cdeda1a4da98fb970c18bfbdaec2025-02-03T01:03:58ZengWileyCase Reports in Urology2090-696X2090-69782020-01-01202010.1155/2020/88276468827646Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous ComponentRami Halabi0Maher Abdessater1Johnny Boustany2Anthony Kanbar3Halim Akl4Joey El Khoury5Charbel El Hachem6Raghid El Khoury7Department of Urology, Notre Dame des Secours University Hospital Center (CHUNDS), Byblos City, LebanonDepartment of Urology, Notre Dame des Secours University Hospital Center (CHUNDS), Byblos City, LebanonDepartment of Urology, Notre Dame des Secours University Hospital Center (CHUNDS), Byblos City, LebanonDepartment of Urology, Notre Dame des Secours University Hospital Center (CHUNDS), Byblos City, LebanonDepartment of Urology, Notre Dame des Secours University Hospital Center (CHUNDS), Byblos City, LebanonDepartment of Urology, Notre Dame des Secours University Hospital Center (CHUNDS), Byblos City, LebanonDepartment of Urology, Notre Dame des Secours University Hospital Center (CHUNDS), Byblos City, LebanonDepartment of Urology, Notre Dame des Secours University Hospital Center (CHUNDS), Byblos City, LebanonLarge cell neuroendocrine carcinoma (LCNC) is one of the rarest types of bladder cancer occurring in <1%. Either pure or mixed with another component, it remains one of the most aggressive types of bladder cancer. We report a case of LCNC of the bladder with an adenocarcinomatous component. The patient was a 64-year-old smoker male, who presented for the first time with dysuria and hematuria. A bladder tumor invading the anterior and right lateral bladder walls was discovered, without any secondary localizations. Tumor biopsy showed an LCNC with adenocarcinomatous components. The patient was treated by recurrent tumor resections, chemotherapy, and radiotherapy. No improvement was noted despite close follow-up and adequate treatment. Neuroendocrine bladder tumor is known to have an aggressive, rapid, and disadvantageous evolution. Multiple case reports were published so far, and a recent review was conducted in March 2020 by Sanguedolce et al. (2020). More cases are needed to establish the best management plan for this type of tumor.http://dx.doi.org/10.1155/2020/8827646 |
| spellingShingle | Rami Halabi Maher Abdessater Johnny Boustany Anthony Kanbar Halim Akl Joey El Khoury Charbel El Hachem Raghid El Khoury Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component Case Reports in Urology |
| title | Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component |
| title_full | Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component |
| title_fullStr | Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component |
| title_full_unstemmed | Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component |
| title_short | Large Cell Neuroendocrine Carcinoma of the Bladder with Adenocarcinomatous Component |
| title_sort | large cell neuroendocrine carcinoma of the bladder with adenocarcinomatous component |
| url | http://dx.doi.org/10.1155/2020/8827646 |
| work_keys_str_mv | AT ramihalabi largecellneuroendocrinecarcinomaofthebladderwithadenocarcinomatouscomponent AT maherabdessater largecellneuroendocrinecarcinomaofthebladderwithadenocarcinomatouscomponent AT johnnyboustany largecellneuroendocrinecarcinomaofthebladderwithadenocarcinomatouscomponent AT anthonykanbar largecellneuroendocrinecarcinomaofthebladderwithadenocarcinomatouscomponent AT halimakl largecellneuroendocrinecarcinomaofthebladderwithadenocarcinomatouscomponent AT joeyelkhoury largecellneuroendocrinecarcinomaofthebladderwithadenocarcinomatouscomponent AT charbelelhachem largecellneuroendocrinecarcinomaofthebladderwithadenocarcinomatouscomponent AT raghidelkhoury largecellneuroendocrinecarcinomaofthebladderwithadenocarcinomatouscomponent |