Analysis of clinicopathological factors associate with the visibility of early gastric cancer in endoscopic examination and usefulness of linked color imaging: A multicenter prospective study.
<h4>Background</h4>This study investigated clinicopathological factors associated with the visibility of early gastric cancer and the efficacy of linked color imaging.<h4>Methods</h4>Patients with early gastric cancer who underwent endoscopic treatment between April 2021 and...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2024-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0312385 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850184949661958144 |
|---|---|
| author | Kensuke Fukuda Kazuhiro Mizukami Daisuke Yamaguch Yuichiro Tanaka Kazutoshi Hashiguchi Takashi Akutagawa Ryo Shimoda Sho Suzuki Tadashi Miike Yorinobu Sumida Hidehito Maeda Fumisato Sasaki Ryosuke Gushima Hideaki Miyamoto Keiichi Hashiguchi Naoyuki Yamaguchi Tetsuya Ohira Tetsu Kinjo Ken Ohnita Tomohiko Moriyama Kensei Ohtsu Akira Aso Ryo Ogawa Tetsuya Ueo Masahide Fukuda |
| author_facet | Kensuke Fukuda Kazuhiro Mizukami Daisuke Yamaguch Yuichiro Tanaka Kazutoshi Hashiguchi Takashi Akutagawa Ryo Shimoda Sho Suzuki Tadashi Miike Yorinobu Sumida Hidehito Maeda Fumisato Sasaki Ryosuke Gushima Hideaki Miyamoto Keiichi Hashiguchi Naoyuki Yamaguchi Tetsuya Ohira Tetsu Kinjo Ken Ohnita Tomohiko Moriyama Kensei Ohtsu Akira Aso Ryo Ogawa Tetsuya Ueo Masahide Fukuda |
| author_sort | Kensuke Fukuda |
| collection | DOAJ |
| description | <h4>Background</h4>This study investigated clinicopathological factors associated with the visibility of early gastric cancer and the efficacy of linked color imaging.<h4>Methods</h4>Patients with early gastric cancer who underwent endoscopic treatment between April 2021 and July 2022 were enrolled. All cases underwent white light imaging and linked color imaging. Three experts evaluated lesion visibility using a visual analog scale. A mean score ≥3 on white light imaging was defined as "good visibility", and <3 as "poor visibility". We extracted patient information and endoscopic and pathological data for the lesion and background mucosa, analyzed factors associated with the visibility of early gastric cancer, and compared visibility between white light imaging and linked color imaging.<h4>Results</h4>Ninety-seven lesions were analyzed, with good visibility in 49 and poor visibility in 48. Multivariate analysis revealed small lesion size (odds ratio 1.89) and presence of endoscopic intestinal metaplasia (odds ratio 0.49) as significantly associated with the poor visibility of early gastric cancer. Mean visibility score was significantly higher for linked color imaging (P<0.001). Mean score for linked color imaging was significantly higher in the poor visibility group (P<0.001), but not significantly different in the good visibility group (P = 0.292). Mean score was significantly higher with linked color imaging in cases with endoscopic intestinal metaplasia (P = 0.0496) and lesions <20 mm in diameter (<10 mm, P = 0.002; 10-20 mm, P = 0.004).<h4>Conclusions</h4>Lesion size and endoscopic intestinal metaplasia are associated with the visibility of early gastric cancer in white light imaging. Linked color imaging improves visibility of gastric cancer with these factors. |
| format | Article |
| id | doaj-art-a0b90d9dae5844c9a03dd32e4b57a72d |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-a0b90d9dae5844c9a03dd32e4b57a72d2025-08-20T02:16:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-011911e031238510.1371/journal.pone.0312385Analysis of clinicopathological factors associate with the visibility of early gastric cancer in endoscopic examination and usefulness of linked color imaging: A multicenter prospective study.Kensuke FukudaKazuhiro MizukamiDaisuke YamaguchYuichiro TanakaKazutoshi HashiguchiTakashi AkutagawaRyo ShimodaSho SuzukiTadashi MiikeYorinobu SumidaHidehito MaedaFumisato SasakiRyosuke GushimaHideaki MiyamotoKeiichi HashiguchiNaoyuki YamaguchiTetsuya OhiraTetsu KinjoKen OhnitaTomohiko MoriyamaKensei OhtsuAkira AsoRyo OgawaTetsuya UeoMasahide Fukuda<h4>Background</h4>This study investigated clinicopathological factors associated with the visibility of early gastric cancer and the efficacy of linked color imaging.<h4>Methods</h4>Patients with early gastric cancer who underwent endoscopic treatment between April 2021 and July 2022 were enrolled. All cases underwent white light imaging and linked color imaging. Three experts evaluated lesion visibility using a visual analog scale. A mean score ≥3 on white light imaging was defined as "good visibility", and <3 as "poor visibility". We extracted patient information and endoscopic and pathological data for the lesion and background mucosa, analyzed factors associated with the visibility of early gastric cancer, and compared visibility between white light imaging and linked color imaging.<h4>Results</h4>Ninety-seven lesions were analyzed, with good visibility in 49 and poor visibility in 48. Multivariate analysis revealed small lesion size (odds ratio 1.89) and presence of endoscopic intestinal metaplasia (odds ratio 0.49) as significantly associated with the poor visibility of early gastric cancer. Mean visibility score was significantly higher for linked color imaging (P<0.001). Mean score for linked color imaging was significantly higher in the poor visibility group (P<0.001), but not significantly different in the good visibility group (P = 0.292). Mean score was significantly higher with linked color imaging in cases with endoscopic intestinal metaplasia (P = 0.0496) and lesions <20 mm in diameter (<10 mm, P = 0.002; 10-20 mm, P = 0.004).<h4>Conclusions</h4>Lesion size and endoscopic intestinal metaplasia are associated with the visibility of early gastric cancer in white light imaging. Linked color imaging improves visibility of gastric cancer with these factors.https://doi.org/10.1371/journal.pone.0312385 |
| spellingShingle | Kensuke Fukuda Kazuhiro Mizukami Daisuke Yamaguch Yuichiro Tanaka Kazutoshi Hashiguchi Takashi Akutagawa Ryo Shimoda Sho Suzuki Tadashi Miike Yorinobu Sumida Hidehito Maeda Fumisato Sasaki Ryosuke Gushima Hideaki Miyamoto Keiichi Hashiguchi Naoyuki Yamaguchi Tetsuya Ohira Tetsu Kinjo Ken Ohnita Tomohiko Moriyama Kensei Ohtsu Akira Aso Ryo Ogawa Tetsuya Ueo Masahide Fukuda Analysis of clinicopathological factors associate with the visibility of early gastric cancer in endoscopic examination and usefulness of linked color imaging: A multicenter prospective study. PLoS ONE |
| title | Analysis of clinicopathological factors associate with the visibility of early gastric cancer in endoscopic examination and usefulness of linked color imaging: A multicenter prospective study. |
| title_full | Analysis of clinicopathological factors associate with the visibility of early gastric cancer in endoscopic examination and usefulness of linked color imaging: A multicenter prospective study. |
| title_fullStr | Analysis of clinicopathological factors associate with the visibility of early gastric cancer in endoscopic examination and usefulness of linked color imaging: A multicenter prospective study. |
| title_full_unstemmed | Analysis of clinicopathological factors associate with the visibility of early gastric cancer in endoscopic examination and usefulness of linked color imaging: A multicenter prospective study. |
| title_short | Analysis of clinicopathological factors associate with the visibility of early gastric cancer in endoscopic examination and usefulness of linked color imaging: A multicenter prospective study. |
| title_sort | analysis of clinicopathological factors associate with the visibility of early gastric cancer in endoscopic examination and usefulness of linked color imaging a multicenter prospective study |
| url | https://doi.org/10.1371/journal.pone.0312385 |
| work_keys_str_mv | AT kensukefukuda analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT kazuhiromizukami analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT daisukeyamaguch analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT yuichirotanaka analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT kazutoshihashiguchi analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT takashiakutagawa analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT ryoshimoda analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT shosuzuki analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT tadashimiike analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT yorinobusumida analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT hidehitomaeda analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT fumisatosasaki analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT ryosukegushima analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT hideakimiyamoto analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT keiichihashiguchi analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT naoyukiyamaguchi analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT tetsuyaohira analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT tetsukinjo analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT kenohnita analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT tomohikomoriyama analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT kenseiohtsu analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT akiraaso analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT ryoogawa analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT tetsuyaueo analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy AT masahidefukuda analysisofclinicopathologicalfactorsassociatewiththevisibilityofearlygastriccancerinendoscopicexaminationandusefulnessoflinkedcolorimagingamulticenterprospectivestudy |