Trends in the incidence and survival of patients with esophageal cancer: A SEER database analysis
Background Recent studies have indicated that the incidence of esophageal cancer has declined in the past decade in the U.S. However, trends in the incidence and survival have not been thoroughly examined. Methods Data from 46 063 patients with esophageal cancer between 1973 and 2015 were collected...
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| Format: | Article |
| Language: | English |
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Wiley
2020-05-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.13311 |
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| author | Haiqi He Nanzheng Chen Yue Hou Zhe Wang Yong Zhang Guangjian Zhang Junke Fu |
| author_facet | Haiqi He Nanzheng Chen Yue Hou Zhe Wang Yong Zhang Guangjian Zhang Junke Fu |
| author_sort | Haiqi He |
| collection | DOAJ |
| description | Background Recent studies have indicated that the incidence of esophageal cancer has declined in the past decade in the U.S. However, trends in the incidence and survival have not been thoroughly examined. Methods Data from 46 063 patients with esophageal cancer between 1973 and 2015 were collected from the Surveillance, Epidemiology, and End Results database. The trends in the age‐adjusted incidence and survival were analyzed using joinpoint regression models. Results The age‐adjusted incidence of esophageal cancer increased from 5.55 to 7.44 per 100 000 person‐years between 1973 and 2004. Later, it decreased at an annual percentage change of 1.23%. In the last 40 years, the strong male predominance increased slightly. Importantly, the percentage of patients with localized stage of squamous cell cancer decreased. It was observed that the incidence of esophageal squamous cell carcinoma declined since 1986, while the incidence of esophageal adenocarcinoma sharply increased since 1973 and surpassed the rate of squamous cell cancer, mainly due to the increase in the incidence among men. Consistently, the estimated 40‐year limited‐duration prevalence of esophageal adenocarcinoma was higher than that of esophageal squamous cell carcinoma. Additionally, we observed a modest but significant improvement in survival during the study period. Conclusion The incidence of esophageal squamous cell carcinoma has decreased significantly over the past four decades in the U.S., while the incidence of adenocarcinoma has increased, particularly among men. Overall, the long‐term survival of patients with esophageal cancer is poor but it has improved over the past decades, especially for the localized disease. Key points Significant findings of the study The incidence of esophageal cancer has decreased at an annual percentage change of 1.23% since 2004. The incidence of esophageal adenocarcinoma has sharply increased since 1973 and surpassed the rate of squamous cell cancer, mainly due to the increase in the incidence among men. What this study adds There has been a shift in the prevalence of esophageal cancer histological subtypes over the past decades in the U.S. We found that the incidence of esophageal squamous cell carcinoma has continued to decrease, while the esophageal adenocarcinoma rate has continued to increase. |
| format | Article |
| id | doaj-art-a0b693cc44784d59afd7cb78f6fdd7eb |
| institution | Kabale University |
| issn | 1759-7706 1759-7714 |
| language | English |
| publishDate | 2020-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj-art-a0b693cc44784d59afd7cb78f6fdd7eb2025-08-26T10:24:34ZengWileyThoracic Cancer1759-77061759-77142020-05-011151121112810.1111/1759-7714.13311Trends in the incidence and survival of patients with esophageal cancer: A SEER database analysisHaiqi He0Nanzheng Chen1Yue Hou2Zhe Wang3Yong Zhang4Guangjian Zhang5Junke Fu6Department of Thoracic Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Thoracic Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Thoracic Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Thoracic Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Thoracic Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Thoracic Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaDepartment of Thoracic Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an ChinaBackground Recent studies have indicated that the incidence of esophageal cancer has declined in the past decade in the U.S. However, trends in the incidence and survival have not been thoroughly examined. Methods Data from 46 063 patients with esophageal cancer between 1973 and 2015 were collected from the Surveillance, Epidemiology, and End Results database. The trends in the age‐adjusted incidence and survival were analyzed using joinpoint regression models. Results The age‐adjusted incidence of esophageal cancer increased from 5.55 to 7.44 per 100 000 person‐years between 1973 and 2004. Later, it decreased at an annual percentage change of 1.23%. In the last 40 years, the strong male predominance increased slightly. Importantly, the percentage of patients with localized stage of squamous cell cancer decreased. It was observed that the incidence of esophageal squamous cell carcinoma declined since 1986, while the incidence of esophageal adenocarcinoma sharply increased since 1973 and surpassed the rate of squamous cell cancer, mainly due to the increase in the incidence among men. Consistently, the estimated 40‐year limited‐duration prevalence of esophageal adenocarcinoma was higher than that of esophageal squamous cell carcinoma. Additionally, we observed a modest but significant improvement in survival during the study period. Conclusion The incidence of esophageal squamous cell carcinoma has decreased significantly over the past four decades in the U.S., while the incidence of adenocarcinoma has increased, particularly among men. Overall, the long‐term survival of patients with esophageal cancer is poor but it has improved over the past decades, especially for the localized disease. Key points Significant findings of the study The incidence of esophageal cancer has decreased at an annual percentage change of 1.23% since 2004. The incidence of esophageal adenocarcinoma has sharply increased since 1973 and surpassed the rate of squamous cell cancer, mainly due to the increase in the incidence among men. What this study adds There has been a shift in the prevalence of esophageal cancer histological subtypes over the past decades in the U.S. We found that the incidence of esophageal squamous cell carcinoma has continued to decrease, while the esophageal adenocarcinoma rate has continued to increase.https://doi.org/10.1111/1759-7714.13311esophageal cancerincidenceprevalenceSEERsurvival |
| spellingShingle | Haiqi He Nanzheng Chen Yue Hou Zhe Wang Yong Zhang Guangjian Zhang Junke Fu Trends in the incidence and survival of patients with esophageal cancer: A SEER database analysis Thoracic Cancer esophageal cancer incidence prevalence SEER survival |
| title | Trends in the incidence and survival of patients with esophageal cancer: A SEER database analysis |
| title_full | Trends in the incidence and survival of patients with esophageal cancer: A SEER database analysis |
| title_fullStr | Trends in the incidence and survival of patients with esophageal cancer: A SEER database analysis |
| title_full_unstemmed | Trends in the incidence and survival of patients with esophageal cancer: A SEER database analysis |
| title_short | Trends in the incidence and survival of patients with esophageal cancer: A SEER database analysis |
| title_sort | trends in the incidence and survival of patients with esophageal cancer a seer database analysis |
| topic | esophageal cancer incidence prevalence SEER survival |
| url | https://doi.org/10.1111/1759-7714.13311 |
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