Serum uric acid level and subclinical left ventricular dysfunction: a community‐based cohort study
Abstract Aims Although serum uric acid (SUA) level is correlated with oxidative stress and serves as a marker of poor prognosis in heart failure patients, its possible association with subclinical left ventricular (LV) dysfunction has not been evaluated. This study aimed to investigate the associati...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-06-01
|
| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.12691 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832544422782304256 |
|---|---|
| author | Koki Nakanishi Masao Daimon Yuriko Yoshida Jumpei Ishiwata Naoko Sawada Megumi Hirokawa Hidehiro Kaneko Tomoko Nakao Yoshiko Mizuno Hiroyuki Morita Marco R. Di Tullio Shunichi Homma Issei Komuro |
| author_facet | Koki Nakanishi Masao Daimon Yuriko Yoshida Jumpei Ishiwata Naoko Sawada Megumi Hirokawa Hidehiro Kaneko Tomoko Nakao Yoshiko Mizuno Hiroyuki Morita Marco R. Di Tullio Shunichi Homma Issei Komuro |
| author_sort | Koki Nakanishi |
| collection | DOAJ |
| description | Abstract Aims Although serum uric acid (SUA) level is correlated with oxidative stress and serves as a marker of poor prognosis in heart failure patients, its possible association with subclinical left ventricular (LV) dysfunction has not been evaluated. This study aimed to investigate the association between SUA and subclinical LV dysfunction in a sample of a general population without overt cardiac disease. Methods and results We examined 1175 participants who underwent extensive cardiovascular health check‐up including laboratory tests and speckle‐tracking echocardiography to assess LV global longitudinal strain (GLS). The association of SUA concentration, as a continuous variable and a categorical variable using quartiles, with the presence of abnormal LVGLS was assessed. Mean age was 62 ± 12 years, and 656 (56%) were male participants. Mean SUA was 5.6 ± 1.3 mg/dL (25th–75th percentile, 4.6–6.5 mg/dL). The prevalence of abnormal LVGLS (greater than –18.6%) was greatest in the upper quartile of SUA. In multivariable analysis, SUA as a continuous variable was significantly associated with abnormal LVGLS [adjusted odds ratio (OR), 1.26 per 1 mg/dL; P = 0.008] independent of traditional cardiovascular risk factors, pertinent laboratory parameters and echocardiographic measures, and medications. In the categorical analysis, the upper quartile of SUA was independently associated with abnormal LVGLS in a fully adjusted model (adjusted OR, 2.28 vs. lowest quartile; P = 0.020). Conclusions In a sample of the general population, an elevated SUA was independently associated with subclinical LV dysfunction. Assessment of LVGLS may add important prognostic information in individuals with elevated SUA, even in the absence of overt cardiac disease. |
| format | Article |
| id | doaj-art-a0b1cadbd0d2495aabb29147a8f070ad |
| institution | Kabale University |
| issn | 2055-5822 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj-art-a0b1cadbd0d2495aabb29147a8f070ad2025-02-03T10:25:46ZengWileyESC Heart Failure2055-58222020-06-01731031103810.1002/ehf2.12691Serum uric acid level and subclinical left ventricular dysfunction: a community‐based cohort studyKoki Nakanishi0Masao Daimon1Yuriko Yoshida2Jumpei Ishiwata3Naoko Sawada4Megumi Hirokawa5Hidehiro Kaneko6Tomoko Nakao7Yoshiko Mizuno8Hiroyuki Morita9Marco R. Di Tullio10Shunichi Homma11Issei Komuro12Department of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanDepartment of Medicine Columbia University New York NY 10032 USADepartment of Medicine Columbia University New York NY 10032 USADepartment of Cardiovascular Medicine The University of Tokyo Tokyo JapanAbstract Aims Although serum uric acid (SUA) level is correlated with oxidative stress and serves as a marker of poor prognosis in heart failure patients, its possible association with subclinical left ventricular (LV) dysfunction has not been evaluated. This study aimed to investigate the association between SUA and subclinical LV dysfunction in a sample of a general population without overt cardiac disease. Methods and results We examined 1175 participants who underwent extensive cardiovascular health check‐up including laboratory tests and speckle‐tracking echocardiography to assess LV global longitudinal strain (GLS). The association of SUA concentration, as a continuous variable and a categorical variable using quartiles, with the presence of abnormal LVGLS was assessed. Mean age was 62 ± 12 years, and 656 (56%) were male participants. Mean SUA was 5.6 ± 1.3 mg/dL (25th–75th percentile, 4.6–6.5 mg/dL). The prevalence of abnormal LVGLS (greater than –18.6%) was greatest in the upper quartile of SUA. In multivariable analysis, SUA as a continuous variable was significantly associated with abnormal LVGLS [adjusted odds ratio (OR), 1.26 per 1 mg/dL; P = 0.008] independent of traditional cardiovascular risk factors, pertinent laboratory parameters and echocardiographic measures, and medications. In the categorical analysis, the upper quartile of SUA was independently associated with abnormal LVGLS in a fully adjusted model (adjusted OR, 2.28 vs. lowest quartile; P = 0.020). Conclusions In a sample of the general population, an elevated SUA was independently associated with subclinical LV dysfunction. Assessment of LVGLS may add important prognostic information in individuals with elevated SUA, even in the absence of overt cardiac disease.https://doi.org/10.1002/ehf2.12691EchocardiographyGlobal longitudinal strainPrimary preventionUric acid |
| spellingShingle | Koki Nakanishi Masao Daimon Yuriko Yoshida Jumpei Ishiwata Naoko Sawada Megumi Hirokawa Hidehiro Kaneko Tomoko Nakao Yoshiko Mizuno Hiroyuki Morita Marco R. Di Tullio Shunichi Homma Issei Komuro Serum uric acid level and subclinical left ventricular dysfunction: a community‐based cohort study ESC Heart Failure Echocardiography Global longitudinal strain Primary prevention Uric acid |
| title | Serum uric acid level and subclinical left ventricular dysfunction: a community‐based cohort study |
| title_full | Serum uric acid level and subclinical left ventricular dysfunction: a community‐based cohort study |
| title_fullStr | Serum uric acid level and subclinical left ventricular dysfunction: a community‐based cohort study |
| title_full_unstemmed | Serum uric acid level and subclinical left ventricular dysfunction: a community‐based cohort study |
| title_short | Serum uric acid level and subclinical left ventricular dysfunction: a community‐based cohort study |
| title_sort | serum uric acid level and subclinical left ventricular dysfunction a community based cohort study |
| topic | Echocardiography Global longitudinal strain Primary prevention Uric acid |
| url | https://doi.org/10.1002/ehf2.12691 |
| work_keys_str_mv | AT kokinakanishi serumuricacidlevelandsubclinicalleftventriculardysfunctionacommunitybasedcohortstudy AT masaodaimon serumuricacidlevelandsubclinicalleftventriculardysfunctionacommunitybasedcohortstudy AT yurikoyoshida serumuricacidlevelandsubclinicalleftventriculardysfunctionacommunitybasedcohortstudy AT jumpeiishiwata serumuricacidlevelandsubclinicalleftventriculardysfunctionacommunitybasedcohortstudy AT naokosawada serumuricacidlevelandsubclinicalleftventriculardysfunctionacommunitybasedcohortstudy AT megumihirokawa serumuricacidlevelandsubclinicalleftventriculardysfunctionacommunitybasedcohortstudy AT hidehirokaneko serumuricacidlevelandsubclinicalleftventriculardysfunctionacommunitybasedcohortstudy AT tomokonakao serumuricacidlevelandsubclinicalleftventriculardysfunctionacommunitybasedcohortstudy AT yoshikomizuno serumuricacidlevelandsubclinicalleftventriculardysfunctionacommunitybasedcohortstudy AT hiroyukimorita serumuricacidlevelandsubclinicalleftventriculardysfunctionacommunitybasedcohortstudy AT marcorditullio serumuricacidlevelandsubclinicalleftventriculardysfunctionacommunitybasedcohortstudy AT shunichihomma serumuricacidlevelandsubclinicalleftventriculardysfunctionacommunitybasedcohortstudy AT isseikomuro serumuricacidlevelandsubclinicalleftventriculardysfunctionacommunitybasedcohortstudy |