Granulocytic Sarcoma of the Male Breast in Acute Myeloblastic Leukemia with Concurrent Deletion of 5q and Trisomy 8
We describe a unique case of Granulocytic Sarcoma (GS) in a male, who presented to us with a painless right breast mass without any prior history of Leukemia. GS is an extramedullary tumor of myeloproliferative precursors and may involve multiple sites of the body, but involvement of male breast is...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/194312 |
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| author | Muhammad Rizwan Md. Monirul Islam Zia ur Rehman |
| author_facet | Muhammad Rizwan Md. Monirul Islam Zia ur Rehman |
| author_sort | Muhammad Rizwan |
| collection | DOAJ |
| description | We describe a unique case of Granulocytic Sarcoma (GS) in a male, who presented to us with a painless right breast mass without any prior history of Leukemia. GS is an extramedullary tumor of myeloproliferative precursors and may involve multiple sites of the body, but involvement of male breast is extremely rare. In the absence of clinical history or hematological abnormality, GS may be misdiagnosed, depending on the degree of myeloid differentiation present within the tumor. Often it is misdiagnosed as lymphoma. Diagnosis is made by finding eosinophilic myelocytes, myeloperoxidase, chloroacetate esterase staining, and lysozyme immunostain. Chemotherapy regimens similar to acute myeloid leukemia are recommended to treat GS. Recognition of this rare entity is important because early, aggressive chemotherapy can induce regression of the tumor and improve patient longevity. |
| format | Article |
| id | doaj-art-a0b17e55658b4851a42b61d5845da20d |
| institution | OA Journals |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-a0b17e55658b4851a42b61d5845da20d2025-08-20T02:20:55ZengWileyCase Reports in Hematology2090-65602090-65792012-01-01201210.1155/2012/194312194312Granulocytic Sarcoma of the Male Breast in Acute Myeloblastic Leukemia with Concurrent Deletion of 5q and Trisomy 8Muhammad Rizwan0Md. Monirul Islam1Zia ur Rehman2Department of Internal Medicine, Vidant Medical Center Greenville, NC 27835, USADivision of Pulmonary and Critical Care Medicine, East Carolina University and Vidant Medical Center, Greenville, NC 27835, USADepartments of Pulmonary, Critical Care and Sleep Medicine, Brody School of Medicine, East Carolina University and Vidant Medical Center, Greenville, NC 27835, USAWe describe a unique case of Granulocytic Sarcoma (GS) in a male, who presented to us with a painless right breast mass without any prior history of Leukemia. GS is an extramedullary tumor of myeloproliferative precursors and may involve multiple sites of the body, but involvement of male breast is extremely rare. In the absence of clinical history or hematological abnormality, GS may be misdiagnosed, depending on the degree of myeloid differentiation present within the tumor. Often it is misdiagnosed as lymphoma. Diagnosis is made by finding eosinophilic myelocytes, myeloperoxidase, chloroacetate esterase staining, and lysozyme immunostain. Chemotherapy regimens similar to acute myeloid leukemia are recommended to treat GS. Recognition of this rare entity is important because early, aggressive chemotherapy can induce regression of the tumor and improve patient longevity.http://dx.doi.org/10.1155/2012/194312 |
| spellingShingle | Muhammad Rizwan Md. Monirul Islam Zia ur Rehman Granulocytic Sarcoma of the Male Breast in Acute Myeloblastic Leukemia with Concurrent Deletion of 5q and Trisomy 8 Case Reports in Hematology |
| title | Granulocytic Sarcoma of the Male Breast in Acute Myeloblastic Leukemia with Concurrent Deletion of 5q and Trisomy 8 |
| title_full | Granulocytic Sarcoma of the Male Breast in Acute Myeloblastic Leukemia with Concurrent Deletion of 5q and Trisomy 8 |
| title_fullStr | Granulocytic Sarcoma of the Male Breast in Acute Myeloblastic Leukemia with Concurrent Deletion of 5q and Trisomy 8 |
| title_full_unstemmed | Granulocytic Sarcoma of the Male Breast in Acute Myeloblastic Leukemia with Concurrent Deletion of 5q and Trisomy 8 |
| title_short | Granulocytic Sarcoma of the Male Breast in Acute Myeloblastic Leukemia with Concurrent Deletion of 5q and Trisomy 8 |
| title_sort | granulocytic sarcoma of the male breast in acute myeloblastic leukemia with concurrent deletion of 5q and trisomy 8 |
| url | http://dx.doi.org/10.1155/2012/194312 |
| work_keys_str_mv | AT muhammadrizwan granulocyticsarcomaofthemalebreastinacutemyeloblasticleukemiawithconcurrentdeletionof5qandtrisomy8 AT mdmonirulislam granulocyticsarcomaofthemalebreastinacutemyeloblasticleukemiawithconcurrentdeletionof5qandtrisomy8 AT ziaurrehman granulocyticsarcomaofthemalebreastinacutemyeloblasticleukemiawithconcurrentdeletionof5qandtrisomy8 |