MXene−Graphene Oxide Heterostructured Films for Enhanced Metasurface Plasmonic Biosensing in Continuous Glucose Monitoring
Abstract Non‐invasive biosensors have attracted attention for their potential to obtain continuous, real‐time physiological information through measurements of biochemical markers, such as one of the most important—glucose, in biological fluids. Although some optical sensing materials are used in no...
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| Format: | Article |
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202410376 |
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| author | Rui Li Hongli Fan Youqian Chen Shaoping Yin Gang L. Liu Yanan Li Liping Huang |
| author_facet | Rui Li Hongli Fan Youqian Chen Shaoping Yin Gang L. Liu Yanan Li Liping Huang |
| author_sort | Rui Li |
| collection | DOAJ |
| description | Abstract Non‐invasive biosensors have attracted attention for their potential to obtain continuous, real‐time physiological information through measurements of biochemical markers, such as one of the most important—glucose, in biological fluids. Although some optical sensing materials are used in non‐invasive devices for continuous glucose monitoring (CGM), surface or localized plasmon sensing material are seldom applied in CGM owing to modest sensitivity and bulk sensing apparatus. Herein, a metasurface (MGMSPR) biosensor based on the metasurface plasmon resonance chip modified with heterostructured Ti3C2 MXene−Graphene oxide (MG) is reported, which potentially enables ultra‐sensitive glucose detection. The sensor consists of a dual‐channel microfluidic device integrated with silver mirror enhanced MGMSPR chips. Not only does it promote the entry of glucose oxidase (GOD) into the internal pores and enhance the stable fixation of GOD in the membrane, but also the integration of MG material provides a high specific surface area and unique electronic properties, thereby significantly enhancing the sensitivity of the MGMSPR sensor. The detection limit of MGMSPR biosensor is 106.8 µM. This pioneering approach opens new avenues for monitoring physiological parameters and process analytical technology on an optical platform, providing continuous health monitoring and production process control through optical sensors. |
| format | Article |
| id | doaj-art-a09da72bd56c4db18093d5ef9ced0f20 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | Advanced Science |
| spelling | doaj-art-a09da72bd56c4db18093d5ef9ced0f202025-01-29T09:50:18ZengWileyAdvanced Science2198-38442025-01-01124n/an/a10.1002/advs.202410376MXene−Graphene Oxide Heterostructured Films for Enhanced Metasurface Plasmonic Biosensing in Continuous Glucose MonitoringRui Li0Hongli Fan1Youqian Chen2Shaoping Yin3Gang L. Liu4Yanan Li5Liping Huang6College of Life Science and Technology State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Huazhong University of Science and Technology 1037 LuoYu Road Wuhan 430070 P. R. ChinaCollege of Life Science and Technology State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Huazhong University of Science and Technology 1037 LuoYu Road Wuhan 430070 P. R. ChinaCollege of Life Science and Technology State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Huazhong University of Science and Technology 1037 LuoYu Road Wuhan 430070 P. R. ChinaSchool of Pharmacy Jiangsu Provincial Engineering Research Center of Traditional Chinese Medicine External Medication Development and Application Nanjing University of Chinese Medicine Nanjing 210023 P. R. ChinaCollege of Life Science and Technology State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Huazhong University of Science and Technology 1037 LuoYu Road Wuhan 430070 P. R. ChinaBiosensor R&D Department Liangzhun (Wuhan) Life Technology Co., Ltd. Wuhan 430070 P. R. ChinaCollege of Life Science and Technology State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Huazhong University of Science and Technology 1037 LuoYu Road Wuhan 430070 P. R. ChinaAbstract Non‐invasive biosensors have attracted attention for their potential to obtain continuous, real‐time physiological information through measurements of biochemical markers, such as one of the most important—glucose, in biological fluids. Although some optical sensing materials are used in non‐invasive devices for continuous glucose monitoring (CGM), surface or localized plasmon sensing material are seldom applied in CGM owing to modest sensitivity and bulk sensing apparatus. Herein, a metasurface (MGMSPR) biosensor based on the metasurface plasmon resonance chip modified with heterostructured Ti3C2 MXene−Graphene oxide (MG) is reported, which potentially enables ultra‐sensitive glucose detection. The sensor consists of a dual‐channel microfluidic device integrated with silver mirror enhanced MGMSPR chips. Not only does it promote the entry of glucose oxidase (GOD) into the internal pores and enhance the stable fixation of GOD in the membrane, but also the integration of MG material provides a high specific surface area and unique electronic properties, thereby significantly enhancing the sensitivity of the MGMSPR sensor. The detection limit of MGMSPR biosensor is 106.8 µM. This pioneering approach opens new avenues for monitoring physiological parameters and process analytical technology on an optical platform, providing continuous health monitoring and production process control through optical sensors.https://doi.org/10.1002/advs.202410376glucose monitoringheterostructured materialmetasurface plasmonic sensormicrofluidicsMXene |
| spellingShingle | Rui Li Hongli Fan Youqian Chen Shaoping Yin Gang L. Liu Yanan Li Liping Huang MXene−Graphene Oxide Heterostructured Films for Enhanced Metasurface Plasmonic Biosensing in Continuous Glucose Monitoring Advanced Science glucose monitoring heterostructured material metasurface plasmonic sensor microfluidics MXene |
| title | MXene−Graphene Oxide Heterostructured Films for Enhanced Metasurface Plasmonic Biosensing in Continuous Glucose Monitoring |
| title_full | MXene−Graphene Oxide Heterostructured Films for Enhanced Metasurface Plasmonic Biosensing in Continuous Glucose Monitoring |
| title_fullStr | MXene−Graphene Oxide Heterostructured Films for Enhanced Metasurface Plasmonic Biosensing in Continuous Glucose Monitoring |
| title_full_unstemmed | MXene−Graphene Oxide Heterostructured Films for Enhanced Metasurface Plasmonic Biosensing in Continuous Glucose Monitoring |
| title_short | MXene−Graphene Oxide Heterostructured Films for Enhanced Metasurface Plasmonic Biosensing in Continuous Glucose Monitoring |
| title_sort | mxene graphene oxide heterostructured films for enhanced metasurface plasmonic biosensing in continuous glucose monitoring |
| topic | glucose monitoring heterostructured material metasurface plasmonic sensor microfluidics MXene |
| url | https://doi.org/10.1002/advs.202410376 |
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