Studies on Synthesis of Some New Chalcone and Pyrimidines and their Antibacterial Activity
Pyrimidine-2-one derivatives, 2-[2-{1ʹ-(p-nitrophenyl)-6ʹ-(substituted-phenyl)-pyrimidine-2ʹ-one-4ʹ-yl}-hydrazinomethyl]-3-(p-methoxy phenyl)-quina-zoline-4(3H)-one [4a-j] have been synthesised by the condensation of p-nitro phenylurea and various chalcones, 2-(substituted phenylchalconylhydrazinome...
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2005/690296 |
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| author | Ketan Mistry K. R. Desai |
| author_facet | Ketan Mistry K. R. Desai |
| author_sort | Ketan Mistry |
| collection | DOAJ |
| description | Pyrimidine-2-one derivatives, 2-[2-{1ʹ-(p-nitrophenyl)-6ʹ-(substituted-phenyl)-pyrimidine-2ʹ-one-4ʹ-yl}-hydrazinomethyl]-3-(p-methoxy phenyl)-quina-zoline-4(3H)-one [4a-j] have been synthesised by the condensation of p-nitro phenylurea and various chalcones, 2-(substituted phenylchalconylhydrazinomethyl)-3-(p-methoxyphenyl)-quinazoline-4(3H)-one [3a-j] in the presence of catalytic amount of conc. HCl. And this series of chalcones have been synthesised by the reaction of 2-acetylhydrazinomethyl-3-(substitutedphenyl)-quinazoline-4(3H)-one [2] with different substituted aldehydes in presence of a 2% NaOH solution. These products have been characterized by means of elemental analysis, IR and NMR spectrul studies and tested for antibacterial activities against Staphylococcus aureus, Bacillus subtillis, Escherichia coli and Salmonella typhi. |
| format | Article |
| id | doaj-art-a08c46d7037443dd96eea0725f8f8de6 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-a08c46d7037443dd96eea0725f8f8de62025-02-03T05:57:09ZengWileyE-Journal of Chemistry0973-49452090-98102005-01-012215215610.1155/2005/690296Studies on Synthesis of Some New Chalcone and Pyrimidines and their Antibacterial ActivityKetan Mistry0K. R. Desai1Department of Chemistry Veer Narmad South Gujarat University Surat-395007, IndiaDepartment of Chemistry Veer Narmad South Gujarat University Surat-395007, IndiaPyrimidine-2-one derivatives, 2-[2-{1ʹ-(p-nitrophenyl)-6ʹ-(substituted-phenyl)-pyrimidine-2ʹ-one-4ʹ-yl}-hydrazinomethyl]-3-(p-methoxy phenyl)-quina-zoline-4(3H)-one [4a-j] have been synthesised by the condensation of p-nitro phenylurea and various chalcones, 2-(substituted phenylchalconylhydrazinomethyl)-3-(p-methoxyphenyl)-quinazoline-4(3H)-one [3a-j] in the presence of catalytic amount of conc. HCl. And this series of chalcones have been synthesised by the reaction of 2-acetylhydrazinomethyl-3-(substitutedphenyl)-quinazoline-4(3H)-one [2] with different substituted aldehydes in presence of a 2% NaOH solution. These products have been characterized by means of elemental analysis, IR and NMR spectrul studies and tested for antibacterial activities against Staphylococcus aureus, Bacillus subtillis, Escherichia coli and Salmonella typhi.http://dx.doi.org/10.1155/2005/690296 |
| spellingShingle | Ketan Mistry K. R. Desai Studies on Synthesis of Some New Chalcone and Pyrimidines and their Antibacterial Activity E-Journal of Chemistry |
| title | Studies on Synthesis of Some New Chalcone and Pyrimidines and their Antibacterial Activity |
| title_full | Studies on Synthesis of Some New Chalcone and Pyrimidines and their Antibacterial Activity |
| title_fullStr | Studies on Synthesis of Some New Chalcone and Pyrimidines and their Antibacterial Activity |
| title_full_unstemmed | Studies on Synthesis of Some New Chalcone and Pyrimidines and their Antibacterial Activity |
| title_short | Studies on Synthesis of Some New Chalcone and Pyrimidines and their Antibacterial Activity |
| title_sort | studies on synthesis of some new chalcone and pyrimidines and their antibacterial activity |
| url | http://dx.doi.org/10.1155/2005/690296 |
| work_keys_str_mv | AT ketanmistry studiesonsynthesisofsomenewchalconeandpyrimidinesandtheirantibacterialactivity AT krdesai studiesonsynthesisofsomenewchalconeandpyrimidinesandtheirantibacterialactivity |