Loss of the APP regulator RHBDL4 preserves memory in an Alzheimer’s disease mouse model

Loss of the APP regulator RHBDL4 preserves memory in an Alzheimer’s disease mouse model

Abstract Characteristic cerebral pathological changes of Alzheimer’s disease (AD) such as glucose hypometabolism or the accumulation of cleavage products of the amyloid precursor protein (APP), known as Aβ peptides, lead to sustained endoplasmic reticulum (ER) stress and neurodegeneration. To preser...

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Main Authors: Ylauna Christine Mégane Penalva, Sandra Paschkowsky, Jingyun Yang, Sherilyn Junelle Recinto, Jessica K. Cinkornpumin, Marina Ruelas, Bin Xiao, Albert Nitu, Sin Young Kwon, Helen Yee-Li Wu, Hans Markus Munter, Bernadeta Michalski, Margaret Fahnestock, William A. Pastor, David A. Bennett, Lisa Marie Munter
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07579-z
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