Noradrenergic Modulation of Cognition in Health and Disease
Norepinephrine released by the locus coeruleus modulates cellular processes and synaptic transmission in the central nervous system through its actions at a number of pre- and postsynaptic receptors. This transmitter system facilitates sensory signal detection and promotes waking and arousal, proces...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/6031478 |
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| author | Olga Borodovitsyna Matthew Flamini Daniel Chandler |
| author_facet | Olga Borodovitsyna Matthew Flamini Daniel Chandler |
| author_sort | Olga Borodovitsyna |
| collection | DOAJ |
| description | Norepinephrine released by the locus coeruleus modulates cellular processes and synaptic transmission in the central nervous system through its actions at a number of pre- and postsynaptic receptors. This transmitter system facilitates sensory signal detection and promotes waking and arousal, processes which are necessary for navigating a complex and dynamic sensory environment. In addition to its effects on sensory processing and waking behavior, norepinephrine is now recognized as a contributor to various aspects of cognition, including attention, behavioral flexibility, working memory, and long-term mnemonic processes. Two areas of dense noradrenergic innervation, the prefrontal cortex and the hippocampus, are particularly important with regard to these functions. Due to its role in mediating normal cognitive function, it is reasonable to expect that noradrenergic transmission becomes dysfunctional in a number of neuropsychiatric and neurodegenerative diseases characterized by cognitive deficits. In this review, we summarize the unique role that norepinephrine plays in prefrontal cortical and hippocampal function and how its interaction with its various receptors contributes to cognitive behaviors. We further assess the changes that occur in the noradrenergic system in Alzheimer’s disease, Parkinson’s disease, attention-deficit/hyperactivity disorder, and schizophrenia and how these changes contribute to cognitive decline in these pathologies. |
| format | Article |
| id | doaj-art-a08aa63a77754231bae9eb81a7ec0b7f |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-a08aa63a77754231bae9eb81a7ec0b7f2025-02-03T01:07:25ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/60314786031478Noradrenergic Modulation of Cognition in Health and DiseaseOlga Borodovitsyna0Matthew Flamini1Daniel Chandler2Department of Cell Biology and Neuroscience, Rowan University School of Osteopathic Medicine, Stratford, NJ 08084, USADepartment of Cell Biology and Neuroscience, Rowan University School of Osteopathic Medicine, Stratford, NJ 08084, USADepartment of Cell Biology and Neuroscience, Rowan University School of Osteopathic Medicine, Stratford, NJ 08084, USANorepinephrine released by the locus coeruleus modulates cellular processes and synaptic transmission in the central nervous system through its actions at a number of pre- and postsynaptic receptors. This transmitter system facilitates sensory signal detection and promotes waking and arousal, processes which are necessary for navigating a complex and dynamic sensory environment. In addition to its effects on sensory processing and waking behavior, norepinephrine is now recognized as a contributor to various aspects of cognition, including attention, behavioral flexibility, working memory, and long-term mnemonic processes. Two areas of dense noradrenergic innervation, the prefrontal cortex and the hippocampus, are particularly important with regard to these functions. Due to its role in mediating normal cognitive function, it is reasonable to expect that noradrenergic transmission becomes dysfunctional in a number of neuropsychiatric and neurodegenerative diseases characterized by cognitive deficits. In this review, we summarize the unique role that norepinephrine plays in prefrontal cortical and hippocampal function and how its interaction with its various receptors contributes to cognitive behaviors. We further assess the changes that occur in the noradrenergic system in Alzheimer’s disease, Parkinson’s disease, attention-deficit/hyperactivity disorder, and schizophrenia and how these changes contribute to cognitive decline in these pathologies.http://dx.doi.org/10.1155/2017/6031478 |
| spellingShingle | Olga Borodovitsyna Matthew Flamini Daniel Chandler Noradrenergic Modulation of Cognition in Health and Disease Neural Plasticity |
| title | Noradrenergic Modulation of Cognition in Health and Disease |
| title_full | Noradrenergic Modulation of Cognition in Health and Disease |
| title_fullStr | Noradrenergic Modulation of Cognition in Health and Disease |
| title_full_unstemmed | Noradrenergic Modulation of Cognition in Health and Disease |
| title_short | Noradrenergic Modulation of Cognition in Health and Disease |
| title_sort | noradrenergic modulation of cognition in health and disease |
| url | http://dx.doi.org/10.1155/2017/6031478 |
| work_keys_str_mv | AT olgaborodovitsyna noradrenergicmodulationofcognitioninhealthanddisease AT matthewflamini noradrenergicmodulationofcognitioninhealthanddisease AT danielchandler noradrenergicmodulationofcognitioninhealthanddisease |