Cryoelectrospun elastin-alginate scaffolds as potential cell delivery vehicles for mesenchymal stromal cell therapy

Cryoelectrospun elastin-alginate scaffolds as potential cell delivery vehicles for mesenchymal stromal cell therapy

Abstract Salivary gland fibrosis results in salivary hypofunction whose current treatments are palliative. Mesenchymal stem/stromal cells (MSCs) are anti-fibrotic and anti-inflammatory and provide a promising alternative to treat fibrosis, but face translational challenges due to poor tissue targeti...

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Bibliographic Details
Main Authors: Pujhitha Ramesh, Rafael Pena, Jennifer M. Morrissey, Nicholas Moskwa, Kate Tubbesing, Xulang Zhang, Deirdre Nelson, James Castracane, Alexander Khmaladze, Susan T. Sharfstein, Melinda Larsen, Yubing Xie
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Cryoelectrospinning
Elastin-alginate scaffold
MSC delivery
Fibrosis
Salivary gland
In vivo implantation
Online Access:https://doi.org/10.1038/s41598-025-03822-x
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