Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFα response: A diagnostic tool for immunosuppression?

Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFα response: A diagnostic tool for immunosuppression?

<h4>Background</h4>Sepsis is defined as a dysregulated immune response to infection. Impaired immune response in sepsis, often described as endotoxin tolerance, is characterized by unresponsiveness of monocytes on lipopolysaccharide (LPS) stimulation to release tumor necrosis factor α (T...

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Bibliographic Details
Main Authors: Martin Sebastian Winkler, Anne Rissiek, Marion Priefler, Edzard Schwedhelm, Linda Robbe, Antonia Bauer, Corinne Zahrte, Christian Zoellner, Stefan Kluge, Axel Nierhaus
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0182427&type=printable
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