Exercise-induced bronchoconstriction and non-specific airway hyperreactivity in patients suffering from bronchial asthma
Background/Aim. Physical activity is a common stimulus of asthmatic symptoms manifestation. Airway hyperreactivity is a predisposing cause of exercise induced bronchial obstruction, diagnosed by histamine inhalation. The aim of this study was to determine the relation between the amounts of...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2014-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501402191N.pdf |
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| author | Novković Dobrivoje Škuletić Vesna Vulin Aleksandra Cvetković Gordana |
| author_facet | Novković Dobrivoje Škuletić Vesna Vulin Aleksandra Cvetković Gordana |
| author_sort | Novković Dobrivoje |
| collection | DOAJ |
| description | Background/Aim. Physical activity is a common stimulus of asthmatic symptoms
manifestation. Airway hyperreactivity is a predisposing cause of exercise
induced bronchial obstruction, diagnosed by histamine inhalation. The aim of
this study was to determine the relation between the amounts of histamine
needed to induce non-specific airway hyperreactivity and exercise-induced
bronchial obstruction. Methods. This randomized cross-over study included 160
male patients (age 19-27 years) suffering from bronchial asthma who showed
positive results as the reaction after the histamine bronchial provocation
test. Histamine concentrations were in a range of 0.03 to 4 mg/mL. Each
patient participated in the exercise stress test conducted on a conveyor
belt. The results of the exercise stress test were considered positive if the
FEV1 level dropped by at least 15% from its initial value, 5-10 minutes after
the test. Results. All the patients showed positive results as the reaction
after the histamine bronchial provocation test, while 50 of them showed
positive results after the exercise-induced stress test. There was a
statistically highly significant difference in administrated histamine
concentrations between the group of patients that had positive results on
exercise stress test and those who did not (1mg/mL vs 0.5mg/mL; U = 1678; p <
0.01). Also, there was a statistically significant difference concerning the
frequency of the positive results regarding histamine concentration after
induced stress test (χ2 = 10.885; p = 0.001). Among the patients with
positive results, there was a statistically highly significant number of
patients with bronchial obstruction induced by less than 2 mg/mL of histamine
(p < 0.01). A statistically significant relation between the amount of
histamine needed to induce bronchial obstruction and the results of the
exercise stress test (p < 0.01) was also observed after the testing.
Conclusion. In the group of patients with positive results after the
exercise-induced stress test, there were significantly more patients with
positive results to non-specific bronchial provocation test with lower
histamine concentrations. Histamine concentrations needed to induce
non-specific hyperreactivity of asthmatic airway were shown to be related to
the reactivity to physical effort. |
| format | Article |
| id | doaj-art-a06bb0b80a6d4410b2f91e87a63b29cf |
| institution | OA Journals |
| issn | 0042-8450 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-a06bb0b80a6d4410b2f91e87a63b29cf2025-08-20T02:00:39ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502014-01-0171219119410.2298/VSP1402191E0042-84501402191NExercise-induced bronchoconstriction and non-specific airway hyperreactivity in patients suffering from bronchial asthmaNovković Dobrivoje0Škuletić Vesna1Vulin Aleksandra2Cvetković Gordana3Military Medical Academy, Department of Pulmonary Diseases, BelgradeMilitary Medical Academy, Institute of Pathology, BelgradeUniversity Clinic of Cardiology, Institute of Cardiovascular Diseases, Sremska KamenicaMilitary Medical Academy, Department of Pulmonary Diseases, BelgradeBackground/Aim. Physical activity is a common stimulus of asthmatic symptoms manifestation. Airway hyperreactivity is a predisposing cause of exercise induced bronchial obstruction, diagnosed by histamine inhalation. The aim of this study was to determine the relation between the amounts of histamine needed to induce non-specific airway hyperreactivity and exercise-induced bronchial obstruction. Methods. This randomized cross-over study included 160 male patients (age 19-27 years) suffering from bronchial asthma who showed positive results as the reaction after the histamine bronchial provocation test. Histamine concentrations were in a range of 0.03 to 4 mg/mL. Each patient participated in the exercise stress test conducted on a conveyor belt. The results of the exercise stress test were considered positive if the FEV1 level dropped by at least 15% from its initial value, 5-10 minutes after the test. Results. All the patients showed positive results as the reaction after the histamine bronchial provocation test, while 50 of them showed positive results after the exercise-induced stress test. There was a statistically highly significant difference in administrated histamine concentrations between the group of patients that had positive results on exercise stress test and those who did not (1mg/mL vs 0.5mg/mL; U = 1678; p < 0.01). Also, there was a statistically significant difference concerning the frequency of the positive results regarding histamine concentration after induced stress test (χ2 = 10.885; p = 0.001). Among the patients with positive results, there was a statistically highly significant number of patients with bronchial obstruction induced by less than 2 mg/mL of histamine (p < 0.01). A statistically significant relation between the amount of histamine needed to induce bronchial obstruction and the results of the exercise stress test (p < 0.01) was also observed after the testing. Conclusion. In the group of patients with positive results after the exercise-induced stress test, there were significantly more patients with positive results to non-specific bronchial provocation test with lower histamine concentrations. Histamine concentrations needed to induce non-specific hyperreactivity of asthmatic airway were shown to be related to the reactivity to physical effort.http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501402191N.pdfasthmahistaminediagnosisexercise testrespiratory function tests |
| spellingShingle | Novković Dobrivoje Škuletić Vesna Vulin Aleksandra Cvetković Gordana Exercise-induced bronchoconstriction and non-specific airway hyperreactivity in patients suffering from bronchial asthma Vojnosanitetski Pregled asthma histamine diagnosis exercise test respiratory function tests |
| title | Exercise-induced bronchoconstriction and non-specific airway hyperreactivity in patients suffering from bronchial asthma |
| title_full | Exercise-induced bronchoconstriction and non-specific airway hyperreactivity in patients suffering from bronchial asthma |
| title_fullStr | Exercise-induced bronchoconstriction and non-specific airway hyperreactivity in patients suffering from bronchial asthma |
| title_full_unstemmed | Exercise-induced bronchoconstriction and non-specific airway hyperreactivity in patients suffering from bronchial asthma |
| title_short | Exercise-induced bronchoconstriction and non-specific airway hyperreactivity in patients suffering from bronchial asthma |
| title_sort | exercise induced bronchoconstriction and non specific airway hyperreactivity in patients suffering from bronchial asthma |
| topic | asthma histamine diagnosis exercise test respiratory function tests |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501402191N.pdf |
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