Effect of Different Doses of Sugammadex on Recovery and Hemodynamic Parameters in Reversing Neuromuscular Blockade in Patients Undergoing Electroconvulsive Therapy
Objective: This retrospective observational study aimed to investigate the effect of different doses of sugammadex used in reversing neuromuscular blockade in electroconvulsive therapy (ECT) procedures on patient recovery and hemodynamic measurements. Methods: Anesthesia induction was performed usin...
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Galenos Publishing House
2024-03-01
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| Series: | Medeniyet Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-60052 |
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| author | Kadir ARSLAN Gozde UCUKSARAC Hale CETIN ARSLAN Erkan AYDIN Ayca Sultan SAHIN |
| author_facet | Kadir ARSLAN Gozde UCUKSARAC Hale CETIN ARSLAN Erkan AYDIN Ayca Sultan SAHIN |
| author_sort | Kadir ARSLAN |
| collection | DOAJ |
| description | Objective: This retrospective observational study aimed to investigate the effect of different doses of sugammadex used in reversing neuromuscular blockade in electroconvulsive therapy (ECT) procedures on patient recovery and hemodynamic measurements.
Methods: Anesthesia induction was performed using propofol (1 mg/kg) and rocuronium (0.4 mg/kg). Patients were classified into group 2 (2 mg/kg) and group 3 (3 mg/kg) according to the dose of sugammadex used to reverse neuromuscular blockade. The patient's spontaneous breathing time, eye-opening time, time to comply with voluntary commands, time to reach Modified Aldrete score (MAS) 9, complications, and hemodynamic data were analyzed.
Results: In total, 314 ECT sessions were performed on 46 patients. The average age of the patients was 38.3+-12.6 years, and 56.6% (n=26) were male. While the average number of ECTs applied to the patients was 6.8+-2.8, the average seizure duration was 28.2+-12.7 seconds. The most common diagnosis (32.7%) in patients who underwent ECT was bipolar disorder. The average time to recovery of spontaneous breathing, eye-opening time, time to comply with voluntary commands, and time to reach MAS 9 were found to be significantly lower in group 3 (p<0.001, p<0.001, p<0.001, and p=0.002, respectively). Tooth damage was observed in 0.3% (n=1) and tongue abrasion in 0.6% (n=2) of the cases. Hemodynamic measurements were similar between groups (p>0.05).
Conclusions: Sugammadex used at a dose of 3 mg/kg in ECT procedures significantly reduces recovery times compared with 2 mg/kg. However, both doses can be safely and cost-effectively used to reverse the neuromuscular blockade provided by 0.4 mg/kg rocuronium. |
| format | Article |
| id | doaj-art-a06609991d1e4ef9a479000e4dcd50eb |
| institution | Kabale University |
| issn | 2149-2042 2149-4606 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Medeniyet Medical Journal |
| spelling | doaj-art-a06609991d1e4ef9a479000e4dcd50eb2025-01-29T10:26:22ZengGalenos Publishing HouseMedeniyet Medical Journal2149-20422149-46062024-03-01391162310.4274/MMJ.galenos.2024.60052MEDJ-60052Effect of Different Doses of Sugammadex on Recovery and Hemodynamic Parameters in Reversing Neuromuscular Blockade in Patients Undergoing Electroconvulsive TherapyKadir ARSLAN0Gozde UCUKSARAC1Hale CETIN ARSLAN2Erkan AYDIN3Ayca Sultan SAHIN4University of Health Sciences Turkey, Kanuni Sultan Suleyman Training and Research Hospital, Clinic of Anesthesiology and Reanimation, Istanbul, TurkeyUniversity of Health Sciences Turkey, Kanuni Sultan Suleyman Training and Research Hospital, Clinic of Anesthesiology and Reanimation, Istanbul, TurkeyUniversity of Health Sciences Turkey, Kanuni Sultan Suleyman Training and Research Hospital, Clinic of Gynecology and Obstetrics, Istanbul, TurkeyUniversity of Health Sciences Turkey, Kanuni Sultan Suleyman Training and Research Hospital, Clinic of Psychiatry, Istanbul, TurkeyUniversity of Health Sciences Turkey, Kanuni Sultan Suleyman Training and Research Hospital, Clinic of Anesthesiology and Reanimation, Istanbul, TurkeyObjective: This retrospective observational study aimed to investigate the effect of different doses of sugammadex used in reversing neuromuscular blockade in electroconvulsive therapy (ECT) procedures on patient recovery and hemodynamic measurements. Methods: Anesthesia induction was performed using propofol (1 mg/kg) and rocuronium (0.4 mg/kg). Patients were classified into group 2 (2 mg/kg) and group 3 (3 mg/kg) according to the dose of sugammadex used to reverse neuromuscular blockade. The patient's spontaneous breathing time, eye-opening time, time to comply with voluntary commands, time to reach Modified Aldrete score (MAS) 9, complications, and hemodynamic data were analyzed. Results: In total, 314 ECT sessions were performed on 46 patients. The average age of the patients was 38.3+-12.6 years, and 56.6% (n=26) were male. While the average number of ECTs applied to the patients was 6.8+-2.8, the average seizure duration was 28.2+-12.7 seconds. The most common diagnosis (32.7%) in patients who underwent ECT was bipolar disorder. The average time to recovery of spontaneous breathing, eye-opening time, time to comply with voluntary commands, and time to reach MAS 9 were found to be significantly lower in group 3 (p<0.001, p<0.001, p<0.001, and p=0.002, respectively). Tooth damage was observed in 0.3% (n=1) and tongue abrasion in 0.6% (n=2) of the cases. Hemodynamic measurements were similar between groups (p>0.05). Conclusions: Sugammadex used at a dose of 3 mg/kg in ECT procedures significantly reduces recovery times compared with 2 mg/kg. However, both doses can be safely and cost-effectively used to reverse the neuromuscular blockade provided by 0.4 mg/kg rocuronium.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-60052electroconvulsive therapyneuromuscular blocking agentsrocuroniumsugammadexanesthesia recovery |
| spellingShingle | Kadir ARSLAN Gozde UCUKSARAC Hale CETIN ARSLAN Erkan AYDIN Ayca Sultan SAHIN Effect of Different Doses of Sugammadex on Recovery and Hemodynamic Parameters in Reversing Neuromuscular Blockade in Patients Undergoing Electroconvulsive Therapy Medeniyet Medical Journal electroconvulsive therapy neuromuscular blocking agents rocuronium sugammadex anesthesia recovery |
| title | Effect of Different Doses of Sugammadex on Recovery and Hemodynamic Parameters in Reversing Neuromuscular Blockade in Patients Undergoing Electroconvulsive Therapy |
| title_full | Effect of Different Doses of Sugammadex on Recovery and Hemodynamic Parameters in Reversing Neuromuscular Blockade in Patients Undergoing Electroconvulsive Therapy |
| title_fullStr | Effect of Different Doses of Sugammadex on Recovery and Hemodynamic Parameters in Reversing Neuromuscular Blockade in Patients Undergoing Electroconvulsive Therapy |
| title_full_unstemmed | Effect of Different Doses of Sugammadex on Recovery and Hemodynamic Parameters in Reversing Neuromuscular Blockade in Patients Undergoing Electroconvulsive Therapy |
| title_short | Effect of Different Doses of Sugammadex on Recovery and Hemodynamic Parameters in Reversing Neuromuscular Blockade in Patients Undergoing Electroconvulsive Therapy |
| title_sort | effect of different doses of sugammadex on recovery and hemodynamic parameters in reversing neuromuscular blockade in patients undergoing electroconvulsive therapy |
| topic | electroconvulsive therapy neuromuscular blocking agents rocuronium sugammadex anesthesia recovery |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-60052 |
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