Research Progress on the Preparation and Application of Decellularized Tendons

Research Progress on the Preparation and Application of Decellularized Tendons

Tendons connect animal skeletons to skeletal muscles, playing a crucial role in weight-bearing and maintaining motor functions. After decellularization, tendon extracellular matrix (tECM) retains the physicochemical characteristics similar to those of native tendons. This has made tECM a promising b...

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Bibliographic Details
Main Authors: Jing Li, Mingxing Wen, Sujuan Zhang, Lingfei Du, Xin Fan, Hao Liang, Hong Wang, Jing Sun, Yuchun Ding, Liangpeng Ge, Jideng Ma, Jinwei Zhang
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Current Issues in Molecular Biology
Subjects:
tendons
decellularization
structural components
applications
Online Access:https://www.mdpi.com/1467-3045/47/4/251
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Summary:Tendons connect animal skeletons to skeletal muscles, playing a crucial role in weight-bearing and maintaining motor functions. After decellularization, tendon extracellular matrix (tECM) retains the physicochemical characteristics similar to those of native tendons. This has made tECM a promising biomaterial in the fields of tissue engineering and regenerative medicine in recent years. This paper summarizes the origin, structure, and ECM components of animal tendons, reviews decellularization methods, and discusses recent advancements in the research and applications of decellularized tendons. Furthermore, it explores future development trends of xenogeneic decellularized tendon materials, aiming to provide a reference for fundamental research and the development of biomaterials related to decellularized tendons.
ISSN:1467-3037
1467-3045

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