Meconium aspiration syndrome: An overview of the literature
Abstract Meconium aspiration syndrome (MAS), a critical cause of morbidity and mortality in term newborns, mostly results from antepartum or postpartum aspiration of meconium-stained amniotic fluid (MSAF). The severity of MAS can vary from self-resolving to serious complications, such as persistent...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Tungs’ Medical Journal |
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| Online Access: | https://doi.org/10.4103/ETMJ.ETMJ-D-23-00025 |
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| author | Hueng-Chuen Fan Chuan-Mu Chen |
| author_facet | Hueng-Chuen Fan Chuan-Mu Chen |
| author_sort | Hueng-Chuen Fan |
| collection | DOAJ |
| description | Abstract Meconium aspiration syndrome (MAS), a critical cause of morbidity and mortality in term newborns, mostly results from antepartum or postpartum aspiration of meconium-stained amniotic fluid (MSAF). The severity of MAS can vary from self-resolving to serious complications, such as persistent pulmonary hypertension or mortality. Concepts regarding pathophysiology and management have undergone drastic changes over the last few decades. For example, in both vigorous and nonvigorous neonates with MSAF, routine endotracheal suctioning during resuscitation is not recommended. There is no proven therapy for MAS; therefore, management is primarily supportive. Respiratory support, surfactant, inhaled nitric oxide, corticosteroids, and bronchoalveolar lavage significantly improved the overall outcome of MAS. This review will provide an overview of the challenges in understanding the complicated pathophysiology of MAS and optimal therapies for treating MAS. |
| format | Article |
| id | doaj-art-a0521dc7bae5477a8724d8e984650618 |
| institution | Kabale University |
| issn | 2071-3592 2949-9720 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tungs’ Medical Journal |
| spelling | doaj-art-a0521dc7bae5477a8724d8e9846506182025-01-25T10:20:06ZengWolters Kluwer Medknow PublicationsTungs’ Medical Journal2071-35922949-97202024-01-0118141110.4103/ETMJ.ETMJ-D-23-00025Meconium aspiration syndrome: An overview of the literatureHueng-Chuen FanChuan-Mu ChenAbstract Meconium aspiration syndrome (MAS), a critical cause of morbidity and mortality in term newborns, mostly results from antepartum or postpartum aspiration of meconium-stained amniotic fluid (MSAF). The severity of MAS can vary from self-resolving to serious complications, such as persistent pulmonary hypertension or mortality. Concepts regarding pathophysiology and management have undergone drastic changes over the last few decades. For example, in both vigorous and nonvigorous neonates with MSAF, routine endotracheal suctioning during resuscitation is not recommended. There is no proven therapy for MAS; therefore, management is primarily supportive. Respiratory support, surfactant, inhaled nitric oxide, corticosteroids, and bronchoalveolar lavage significantly improved the overall outcome of MAS. This review will provide an overview of the challenges in understanding the complicated pathophysiology of MAS and optimal therapies for treating MAS.https://doi.org/10.4103/ETMJ.ETMJ-D-23-00025endotracheal suctionhigh-frequency ventilationinhaled nitric oxidemeconium aspiration syndromepersistent pulmonary hypertensionsurfactant |
| spellingShingle | Hueng-Chuen Fan Chuan-Mu Chen Meconium aspiration syndrome: An overview of the literature Tungs’ Medical Journal endotracheal suction high-frequency ventilation inhaled nitric oxide meconium aspiration syndrome persistent pulmonary hypertension surfactant |
| title | Meconium aspiration syndrome: An overview of the literature |
| title_full | Meconium aspiration syndrome: An overview of the literature |
| title_fullStr | Meconium aspiration syndrome: An overview of the literature |
| title_full_unstemmed | Meconium aspiration syndrome: An overview of the literature |
| title_short | Meconium aspiration syndrome: An overview of the literature |
| title_sort | meconium aspiration syndrome an overview of the literature |
| topic | endotracheal suction high-frequency ventilation inhaled nitric oxide meconium aspiration syndrome persistent pulmonary hypertension surfactant |
| url | https://doi.org/10.4103/ETMJ.ETMJ-D-23-00025 |
| work_keys_str_mv | AT huengchuenfan meconiumaspirationsyndromeanoverviewoftheliterature AT chuanmuchen meconiumaspirationsyndromeanoverviewoftheliterature |