Mitochondrial function in patients affected with fibromyalgia syndrome is impaired and correlates with disease severity
Abstract Fibromyalgia is a musculoskeletal syndrome characterized by chronic widespread pain that is often associated with systemic manifestations. Since mitochondria are the main source of cellular energy, we hypothesized that fibromyalgia syndrome (FMS) could be linked to mitochondrial impairment....
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-81298-x |
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| author | Chiara Macchi Andrea Giachi Isabella Fichtner Silvia Pedretti Piercarlo Sarzi-Puttini Nico Mitro Alberto Corsini Massimiliano Ruscica Roberta Gualtierotti |
| author_facet | Chiara Macchi Andrea Giachi Isabella Fichtner Silvia Pedretti Piercarlo Sarzi-Puttini Nico Mitro Alberto Corsini Massimiliano Ruscica Roberta Gualtierotti |
| author_sort | Chiara Macchi |
| collection | DOAJ |
| description | Abstract Fibromyalgia is a musculoskeletal syndrome characterized by chronic widespread pain that is often associated with systemic manifestations. Since mitochondria are the main source of cellular energy, we hypothesized that fibromyalgia syndrome (FMS) could be linked to mitochondrial impairment. Aim was to study mitochondrial dysfunction in peripheral blood mononuclear cells isolated from 50 patients with primary FMS and 20 apparently healthy controls. Although no differences in mitochondrial basal respiration were observed between patients with primary FMS and healthy controls, a lower median bioenergetic health index (BHI; − 22.1%, p = 0.03), a proxy of mitochondrial function, was found in patients. According to fibromyalgia severity score (FSS), a composite of widespread pain index and symptom severity scale, a lower median BHI (− 18.7%) was found in patients with a FSS ≥ 20 compared to those with a FSS < 20. Negative moderate correlations were found only between BHI and FSS (r = − 0.36) and widespread pain index (r = − 0.38). We demonstrated that patients with FMS had an impaired mitochondrial function. Additionally, we found a mild correlation between the widespread pain index and the BHI, possibly indicating that the altered mitochondrial function, in these patients, narrows musculoskeletal rather than central nervous system involvement. |
| format | Article |
| id | doaj-art-a04eac0d07654ccfa5bc302464a263b7 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-a04eac0d07654ccfa5bc302464a263b72025-02-02T12:25:06ZengNature PortfolioScientific Reports2045-23222024-12-011411910.1038/s41598-024-81298-xMitochondrial function in patients affected with fibromyalgia syndrome is impaired and correlates with disease severityChiara Macchi0Andrea Giachi1Isabella Fichtner2Silvia Pedretti3Piercarlo Sarzi-Puttini4Nico Mitro5Alberto Corsini6Massimiliano Ruscica7Roberta Gualtierotti8Department of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, Università Degli Studi di MilanoDepartment of Pathophysiology and Transplantation, Università Degli Studi di MilanoDepartment of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, Università Degli Studi di MilanoDepartment of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, Università Degli Studi di MilanoRheumatology Department, IRCCS Galeazzi-S.Ambrogio HospitalDepartment of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, Università Degli Studi di MilanoDepartment of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, Università Degli Studi di MilanoDepartment of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, Università Degli Studi di MilanoDepartment of Pathophysiology and Transplantation, Università Degli Studi di MilanoAbstract Fibromyalgia is a musculoskeletal syndrome characterized by chronic widespread pain that is often associated with systemic manifestations. Since mitochondria are the main source of cellular energy, we hypothesized that fibromyalgia syndrome (FMS) could be linked to mitochondrial impairment. Aim was to study mitochondrial dysfunction in peripheral blood mononuclear cells isolated from 50 patients with primary FMS and 20 apparently healthy controls. Although no differences in mitochondrial basal respiration were observed between patients with primary FMS and healthy controls, a lower median bioenergetic health index (BHI; − 22.1%, p = 0.03), a proxy of mitochondrial function, was found in patients. According to fibromyalgia severity score (FSS), a composite of widespread pain index and symptom severity scale, a lower median BHI (− 18.7%) was found in patients with a FSS ≥ 20 compared to those with a FSS < 20. Negative moderate correlations were found only between BHI and FSS (r = − 0.36) and widespread pain index (r = − 0.38). We demonstrated that patients with FMS had an impaired mitochondrial function. Additionally, we found a mild correlation between the widespread pain index and the BHI, possibly indicating that the altered mitochondrial function, in these patients, narrows musculoskeletal rather than central nervous system involvement.https://doi.org/10.1038/s41598-024-81298-x |
| spellingShingle | Chiara Macchi Andrea Giachi Isabella Fichtner Silvia Pedretti Piercarlo Sarzi-Puttini Nico Mitro Alberto Corsini Massimiliano Ruscica Roberta Gualtierotti Mitochondrial function in patients affected with fibromyalgia syndrome is impaired and correlates with disease severity Scientific Reports |
| title | Mitochondrial function in patients affected with fibromyalgia syndrome is impaired and correlates with disease severity |
| title_full | Mitochondrial function in patients affected with fibromyalgia syndrome is impaired and correlates with disease severity |
| title_fullStr | Mitochondrial function in patients affected with fibromyalgia syndrome is impaired and correlates with disease severity |
| title_full_unstemmed | Mitochondrial function in patients affected with fibromyalgia syndrome is impaired and correlates with disease severity |
| title_short | Mitochondrial function in patients affected with fibromyalgia syndrome is impaired and correlates with disease severity |
| title_sort | mitochondrial function in patients affected with fibromyalgia syndrome is impaired and correlates with disease severity |
| url | https://doi.org/10.1038/s41598-024-81298-x |
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