On the utilization of the induced pluripotent stem cell (iPSC) model to study substance use disorders: A scoping review protocol.
<h4>Introduction</h4>Induced pluripotent stem cells (iPSCs) are cells derived from somatic cells via reprogramming techniques. The iPSC approach has been increasingly used in neuropsychiatric research in the last decade. Though substance use disorders (SUDs) are a commonly occurring psyc...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0292238&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832540130862170112 |
|---|---|
| author | Wasiri Niemis Shenita R Peterson Chrisabella Javier Amy Nguyen Sanchi Subiah Rohan H C Palmer |
| author_facet | Wasiri Niemis Shenita R Peterson Chrisabella Javier Amy Nguyen Sanchi Subiah Rohan H C Palmer |
| author_sort | Wasiri Niemis |
| collection | DOAJ |
| description | <h4>Introduction</h4>Induced pluripotent stem cells (iPSCs) are cells derived from somatic cells via reprogramming techniques. The iPSC approach has been increasingly used in neuropsychiatric research in the last decade. Though substance use disorders (SUDs) are a commonly occurring psychiatric disorder, the application of iPSC model in addiction research has been limited. No comprehensive review has been reported. We conducted a scoping review to collate existing evidence on the iPSC technologies applied to SUD research. We aim to identify current knowledge gaps and limitations in order to advance the use of iPSCs in the SUD field.<h4>Methods and analysis</h4>We employed a scoping review using the methodological framework first created by Arksey and O'Malley and further updated by Levac et al. and the Joanna Briggs Institute (JBI). We adopted the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Protocols (PRISMA-P) to report items for the protocol. We searched evidence from four electronic databases: PubMed®, Embase®, Web of Science™, and Scopus®. Primary research, systematic reviews, and meta-analyses were included and limited to studies published in English, at the time from 2007 to March 2022. This is an "ongoing" scoping review. Searched studies will be independently screened, selected, and extracted by two reviewers. Disagreement will be solved by the third reviewer and discussion. Extracted data will be analyzed in descriptive and quantitative approaches, then summarized and presented in appropriate formats. Results will be reported following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guideline and disseminated through a peer-reviewed publication and conference presentations.<h4>Conclusion</h4>To our best knowledge, this is the first comprehensive scoping review of iPSC methods specifically applied to a broad range of addictive drugs/substances that lead to SUDs or misuse behavior.<h4>Registration</h4>This protocol is registered on Zenodo repository (https://zenodo.org/) with doi:10.5281/zenodo.7915252. |
| format | Article |
| id | doaj-art-a04e86116203498a9573016b598691c4 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-a04e86116203498a9573016b598691c42025-02-05T05:32:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-011810e029223810.1371/journal.pone.0292238On the utilization of the induced pluripotent stem cell (iPSC) model to study substance use disorders: A scoping review protocol.Wasiri NiemisShenita R PetersonChrisabella JavierAmy NguyenSanchi SubiahRohan H C Palmer<h4>Introduction</h4>Induced pluripotent stem cells (iPSCs) are cells derived from somatic cells via reprogramming techniques. The iPSC approach has been increasingly used in neuropsychiatric research in the last decade. Though substance use disorders (SUDs) are a commonly occurring psychiatric disorder, the application of iPSC model in addiction research has been limited. No comprehensive review has been reported. We conducted a scoping review to collate existing evidence on the iPSC technologies applied to SUD research. We aim to identify current knowledge gaps and limitations in order to advance the use of iPSCs in the SUD field.<h4>Methods and analysis</h4>We employed a scoping review using the methodological framework first created by Arksey and O'Malley and further updated by Levac et al. and the Joanna Briggs Institute (JBI). We adopted the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Protocols (PRISMA-P) to report items for the protocol. We searched evidence from four electronic databases: PubMed®, Embase®, Web of Science™, and Scopus®. Primary research, systematic reviews, and meta-analyses were included and limited to studies published in English, at the time from 2007 to March 2022. This is an "ongoing" scoping review. Searched studies will be independently screened, selected, and extracted by two reviewers. Disagreement will be solved by the third reviewer and discussion. Extracted data will be analyzed in descriptive and quantitative approaches, then summarized and presented in appropriate formats. Results will be reported following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guideline and disseminated through a peer-reviewed publication and conference presentations.<h4>Conclusion</h4>To our best knowledge, this is the first comprehensive scoping review of iPSC methods specifically applied to a broad range of addictive drugs/substances that lead to SUDs or misuse behavior.<h4>Registration</h4>This protocol is registered on Zenodo repository (https://zenodo.org/) with doi:10.5281/zenodo.7915252.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0292238&type=printable |
| spellingShingle | Wasiri Niemis Shenita R Peterson Chrisabella Javier Amy Nguyen Sanchi Subiah Rohan H C Palmer On the utilization of the induced pluripotent stem cell (iPSC) model to study substance use disorders: A scoping review protocol. PLoS ONE |
| title | On the utilization of the induced pluripotent stem cell (iPSC) model to study substance use disorders: A scoping review protocol. |
| title_full | On the utilization of the induced pluripotent stem cell (iPSC) model to study substance use disorders: A scoping review protocol. |
| title_fullStr | On the utilization of the induced pluripotent stem cell (iPSC) model to study substance use disorders: A scoping review protocol. |
| title_full_unstemmed | On the utilization of the induced pluripotent stem cell (iPSC) model to study substance use disorders: A scoping review protocol. |
| title_short | On the utilization of the induced pluripotent stem cell (iPSC) model to study substance use disorders: A scoping review protocol. |
| title_sort | on the utilization of the induced pluripotent stem cell ipsc model to study substance use disorders a scoping review protocol |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0292238&type=printable |
| work_keys_str_mv | AT wasiriniemis ontheutilizationoftheinducedpluripotentstemcellipscmodeltostudysubstanceusedisordersascopingreviewprotocol AT shenitarpeterson ontheutilizationoftheinducedpluripotentstemcellipscmodeltostudysubstanceusedisordersascopingreviewprotocol AT chrisabellajavier ontheutilizationoftheinducedpluripotentstemcellipscmodeltostudysubstanceusedisordersascopingreviewprotocol AT amynguyen ontheutilizationoftheinducedpluripotentstemcellipscmodeltostudysubstanceusedisordersascopingreviewprotocol AT sanchisubiah ontheutilizationoftheinducedpluripotentstemcellipscmodeltostudysubstanceusedisordersascopingreviewprotocol AT rohanhcpalmer ontheutilizationoftheinducedpluripotentstemcellipscmodeltostudysubstanceusedisordersascopingreviewprotocol |