Diets Rich in Olive Oil, Palm Oil, or Lard Alter Mitochondrial Biogenesis and Mitochondrial Membrane Composition in Rat Liver
Palm oil (crude or refined) and lard are rich in SFA, while olive oil is rich in polyunsaturated fatty acids. SFA are considered harmful to health, while polyunsaturated fatty acids are beneficial to health. The aim of this study was to determine the effect of diets rich in crude PO, refined PO, OO,...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2022/9394356 |
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| author | Youzan Ferdiand Djohan Massara Camara-Cissé Gilles Fouret Béatrice Bonafos Bernard Jover Jean-Paul Cristol Charles Coudray Christine Feillet-Coudray Eric Badia |
| author_facet | Youzan Ferdiand Djohan Massara Camara-Cissé Gilles Fouret Béatrice Bonafos Bernard Jover Jean-Paul Cristol Charles Coudray Christine Feillet-Coudray Eric Badia |
| author_sort | Youzan Ferdiand Djohan |
| collection | DOAJ |
| description | Palm oil (crude or refined) and lard are rich in SFA, while olive oil is rich in polyunsaturated fatty acids. SFA are considered harmful to health, while polyunsaturated fatty acids are beneficial to health. The aim of this study was to determine the effect of diets rich in crude PO, refined PO, OO, or lard on the mitochondrial membrane, the activity of mitochondrial respiratory chain complexes, and mitochondrial biogenesis. This was an experimental study in male Wistar rats fed a diet containing 30% of each oil. Rats had free access to food and water. After being fed for 12 weeks, animals were sacrificed and liver mitochondria were collected. This collection was used to determine membrane potential and ROS production, membrane phospholipid and fatty acid composition, citrate synthase activity and respiratory chain complex, cardiolipin synthase protein expression, and expression of selected genes involved in mitochondrial biogenesis. We found that diets rich in olive oil, palm oil, or lard altered mitochondrial biogenesis by significantly decreasing Pgc1α gene expression and altered the fatty acid composition of rat liver mitochondrial membrane PL. |
| format | Article |
| id | doaj-art-a041f5d6378541a3b2fafd318f0a631a |
| institution | Kabale University |
| issn | 2090-2255 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-a041f5d6378541a3b2fafd318f0a631a2025-02-03T06:06:53ZengWileyBiochemistry Research International2090-22552022-01-01202210.1155/2022/9394356Diets Rich in Olive Oil, Palm Oil, or Lard Alter Mitochondrial Biogenesis and Mitochondrial Membrane Composition in Rat LiverYouzan Ferdiand Djohan0Massara Camara-Cissé1Gilles Fouret2Béatrice Bonafos3Bernard Jover4Jean-Paul Cristol5Charles Coudray6Christine Feillet-Coudray7Eric Badia8Laboratoire de Biochimie CHULaboratoire de Biochimie CHUDMEMDMEMPhyMedExpLaboratoire de BiochimieDMEMDMEMPhyMedExpPalm oil (crude or refined) and lard are rich in SFA, while olive oil is rich in polyunsaturated fatty acids. SFA are considered harmful to health, while polyunsaturated fatty acids are beneficial to health. The aim of this study was to determine the effect of diets rich in crude PO, refined PO, OO, or lard on the mitochondrial membrane, the activity of mitochondrial respiratory chain complexes, and mitochondrial biogenesis. This was an experimental study in male Wistar rats fed a diet containing 30% of each oil. Rats had free access to food and water. After being fed for 12 weeks, animals were sacrificed and liver mitochondria were collected. This collection was used to determine membrane potential and ROS production, membrane phospholipid and fatty acid composition, citrate synthase activity and respiratory chain complex, cardiolipin synthase protein expression, and expression of selected genes involved in mitochondrial biogenesis. We found that diets rich in olive oil, palm oil, or lard altered mitochondrial biogenesis by significantly decreasing Pgc1α gene expression and altered the fatty acid composition of rat liver mitochondrial membrane PL.http://dx.doi.org/10.1155/2022/9394356 |
| spellingShingle | Youzan Ferdiand Djohan Massara Camara-Cissé Gilles Fouret Béatrice Bonafos Bernard Jover Jean-Paul Cristol Charles Coudray Christine Feillet-Coudray Eric Badia Diets Rich in Olive Oil, Palm Oil, or Lard Alter Mitochondrial Biogenesis and Mitochondrial Membrane Composition in Rat Liver Biochemistry Research International |
| title | Diets Rich in Olive Oil, Palm Oil, or Lard Alter Mitochondrial Biogenesis and Mitochondrial Membrane Composition in Rat Liver |
| title_full | Diets Rich in Olive Oil, Palm Oil, or Lard Alter Mitochondrial Biogenesis and Mitochondrial Membrane Composition in Rat Liver |
| title_fullStr | Diets Rich in Olive Oil, Palm Oil, or Lard Alter Mitochondrial Biogenesis and Mitochondrial Membrane Composition in Rat Liver |
| title_full_unstemmed | Diets Rich in Olive Oil, Palm Oil, or Lard Alter Mitochondrial Biogenesis and Mitochondrial Membrane Composition in Rat Liver |
| title_short | Diets Rich in Olive Oil, Palm Oil, or Lard Alter Mitochondrial Biogenesis and Mitochondrial Membrane Composition in Rat Liver |
| title_sort | diets rich in olive oil palm oil or lard alter mitochondrial biogenesis and mitochondrial membrane composition in rat liver |
| url | http://dx.doi.org/10.1155/2022/9394356 |
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