TRPA1 exacerbates selective retinal ganglion cell vulnerability under acute ocular hypertension

TRPA1 exacerbates selective retinal ganglion cell vulnerability under acute ocular hypertension

Abstract Acute ocular hypertension (AOH), a major cause of progressive irreversible vision loss, showed significant retinal ganglion cell (RGC) degeneration as well as selective RGC vulnerability upon functional tests, yet the underlyding mechanisms remain incompletely understood. Here, we report th...

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Bibliographic Details
Main Authors: Wenhan Lu, Yu Wang, Wei Hu, Xinyi Lin, Xiaoyu Tong, Yi Tian, Yuning Chen, Yicong Wang, Yan Xiao, Hongfang Yang, Yi Feng, Xinghuai Sun
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Acta Neuropathologica Communications
Subjects:
TRPA1
Acute ocular hypertension
RGC central projection
Neuronal selective vulnerability
Tissue optical clearing
Online Access:https://doi.org/10.1186/s40478-025-01974-5
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