Structural Characters and Pharmacological Activity of Protopanaxadiol-Type Saponins and Protopanaxatriol-Type Saponins from Ginseng
Ginseng has a long history of drug application in China, which can treat various diseases and achieve significant efficacy. Ginsenosides have always been deemed important ingredients for pharmacological activities. Based on the structural characteristics of steroidal saponins, ginsenosides are mainl...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Advances in Pharmacological and Pharmaceutical Sciences |
| Online Access: | http://dx.doi.org/10.1155/2024/9096774 |
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| author | Lancao Zhang Xiang Gao Chunhui Yang Zuguo Liang Dongsong Guan Tongyi Yuan Wenxiu Qi Daqing Zhao Xiangyan Li Haisi Dong He Zhang |
| author_facet | Lancao Zhang Xiang Gao Chunhui Yang Zuguo Liang Dongsong Guan Tongyi Yuan Wenxiu Qi Daqing Zhao Xiangyan Li Haisi Dong He Zhang |
| author_sort | Lancao Zhang |
| collection | DOAJ |
| description | Ginseng has a long history of drug application in China, which can treat various diseases and achieve significant efficacy. Ginsenosides have always been deemed important ingredients for pharmacological activities. Based on the structural characteristics of steroidal saponins, ginsenosides are mainly divided into protopanaxadiol-type saponins (PDS, mainly including Rb1, Rb2, Rd, Rc, Rh2, CK, and PPD) and protopanaxatriol-type saponins (PTS, mainly including Re, R1, Rg1, Rh1, Rf, and PPT). The structure differences between PDS and PTS result in the differences of pharmacological activities. This paper provides an overview of PDS and PTS, mainly focusing on their chemical profile, pharmacokinetics, hydrolytic metabolism, and pharmacological activities including antioxidant, antifatigue, antiaging, immunodulation, antitumor, cardiovascular protection, neuroprotection, and antidiabetes. It is intended to contribute to an in-depth study of the relationship between PDS and PTS. |
| format | Article |
| id | doaj-art-a02d236b10ed4c668001e227e9e42e07 |
| institution | Kabale University |
| issn | 2633-4690 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological and Pharmaceutical Sciences |
| spelling | doaj-art-a02d236b10ed4c668001e227e9e42e072025-02-03T01:29:29ZengWileyAdvances in Pharmacological and Pharmaceutical Sciences2633-46902024-01-01202410.1155/2024/9096774Structural Characters and Pharmacological Activity of Protopanaxadiol-Type Saponins and Protopanaxatriol-Type Saponins from GinsengLancao Zhang0Xiang Gao1Chunhui Yang2Zuguo Liang3Dongsong Guan4Tongyi Yuan5Wenxiu Qi6Daqing Zhao7Xiangyan Li8Haisi Dong9He Zhang10Northeast Asia Research Institute of Traditional Chinese MedicineCollege of PharmacyNortheast Asia Research Institute of Traditional Chinese MedicineCollege of PharmacyNortheast Asia Research Institute of Traditional Chinese MedicineCollege of PharmacyNortheast Asia Research Institute of Traditional Chinese MedicineNortheast Asia Research Institute of Traditional Chinese MedicineNortheast Asia Research Institute of Traditional Chinese MedicineNortheast Asia Research Institute of Traditional Chinese MedicineNortheast Asia Research Institute of Traditional Chinese MedicineGinseng has a long history of drug application in China, which can treat various diseases and achieve significant efficacy. Ginsenosides have always been deemed important ingredients for pharmacological activities. Based on the structural characteristics of steroidal saponins, ginsenosides are mainly divided into protopanaxadiol-type saponins (PDS, mainly including Rb1, Rb2, Rd, Rc, Rh2, CK, and PPD) and protopanaxatriol-type saponins (PTS, mainly including Re, R1, Rg1, Rh1, Rf, and PPT). The structure differences between PDS and PTS result in the differences of pharmacological activities. This paper provides an overview of PDS and PTS, mainly focusing on their chemical profile, pharmacokinetics, hydrolytic metabolism, and pharmacological activities including antioxidant, antifatigue, antiaging, immunodulation, antitumor, cardiovascular protection, neuroprotection, and antidiabetes. It is intended to contribute to an in-depth study of the relationship between PDS and PTS.http://dx.doi.org/10.1155/2024/9096774 |
| spellingShingle | Lancao Zhang Xiang Gao Chunhui Yang Zuguo Liang Dongsong Guan Tongyi Yuan Wenxiu Qi Daqing Zhao Xiangyan Li Haisi Dong He Zhang Structural Characters and Pharmacological Activity of Protopanaxadiol-Type Saponins and Protopanaxatriol-Type Saponins from Ginseng Advances in Pharmacological and Pharmaceutical Sciences |
| title | Structural Characters and Pharmacological Activity of Protopanaxadiol-Type Saponins and Protopanaxatriol-Type Saponins from Ginseng |
| title_full | Structural Characters and Pharmacological Activity of Protopanaxadiol-Type Saponins and Protopanaxatriol-Type Saponins from Ginseng |
| title_fullStr | Structural Characters and Pharmacological Activity of Protopanaxadiol-Type Saponins and Protopanaxatriol-Type Saponins from Ginseng |
| title_full_unstemmed | Structural Characters and Pharmacological Activity of Protopanaxadiol-Type Saponins and Protopanaxatriol-Type Saponins from Ginseng |
| title_short | Structural Characters and Pharmacological Activity of Protopanaxadiol-Type Saponins and Protopanaxatriol-Type Saponins from Ginseng |
| title_sort | structural characters and pharmacological activity of protopanaxadiol type saponins and protopanaxatriol type saponins from ginseng |
| url | http://dx.doi.org/10.1155/2024/9096774 |
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