Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of <i>Lactobacillus</i> Fermentation Broth in Treating Vulvovaginal Candidiasis
Vulvovaginal candidiasis (VVC), a condition predominantly caused by <i>Candida albicans</i>, affects millions of women worldwide, prompting the need for alternative treatments due to the side effects and increasing resistance associated with conventional imidazole antifungals. This study...
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2024-12-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/11/1/18 |
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| author | Huann-Cheng Horng Jin-Wei Xu Yi-Shan Kuo Yu-Sin Chen Yu-Hsuan Chiu Kuan-Hao Tsui Yu-Tang Tung |
| author_facet | Huann-Cheng Horng Jin-Wei Xu Yi-Shan Kuo Yu-Sin Chen Yu-Hsuan Chiu Kuan-Hao Tsui Yu-Tang Tung |
| author_sort | Huann-Cheng Horng |
| collection | DOAJ |
| description | Vulvovaginal candidiasis (VVC), a condition predominantly caused by <i>Candida albicans</i>, affects millions of women worldwide, prompting the need for alternative treatments due to the side effects and increasing resistance associated with conventional imidazole antifungals. This study investigated VAGINNE<sup>®</sup>, a novel fermentation broth derived from <i>Lactobacillus</i> species, as a potential VVC treatment. Using a BALB/c mouse model of <i>C. albicans</i> infection, we evaluated VAGINNE<sup>®</sup>’s effects on vaginal microbiome composition, inflammatory markers, and tissue integrity. Our findings revealed that VAGINNE<sup>®</sup> treatment enhanced the growth of beneficial <i>Lactobacillus</i> species while suppressing <i>C. albicans</i> proliferation, leading to a more balanced vaginal microbiome. Additionally, VAGINNE<sup>®</sup> significantly reduced pro-inflammatory cytokines (IL-17A, IL-22, IL-23) in vaginal tissues and systemic inflammatory markers (IL-6, IL-1β) in plasma. Histological analysis showed minimal fungal invasion and preserved vaginal epithelial integrity in VAGINNE<sup>®</sup>-treated mice compared to untreated controls. These results suggest that VAGINNE<sup>®</sup> could serve as an effective anti-Candida and anti-inflammatory agent for managing VVC, offering a promising alternative to traditional antifungal treatments. By promoting a healthy vaginal microbiome, reducing inflammation, and maintaining tissue health, this probiotic-based approach presents a novel strategy for addressing VVC, particularly in cases of drug resistance or adverse reactions to standard therapies. This study underscores the potential of microbiome-modulating strategies in managing vaginal infections, paving the way for more targeted and side-effect-free VVC treatments. |
| format | Article |
| id | doaj-art-a022d32fca8a4930aad2318028ae10ab |
| institution | Kabale University |
| issn | 2309-608X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj-art-a022d32fca8a4930aad2318028ae10ab2025-01-24T13:37:14ZengMDPI AGJournal of Fungi2309-608X2024-12-011111810.3390/jof11010018Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of <i>Lactobacillus</i> Fermentation Broth in Treating Vulvovaginal CandidiasisHuann-Cheng Horng0Jin-Wei Xu1Yi-Shan Kuo2Yu-Sin Chen3Yu-Hsuan Chiu4Kuan-Hao Tsui5Yu-Tang Tung6Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, TaiwanDepartment of Forestry, National Chung Hsing University, Taichung 402, TaiwanGraduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, TaiwanGraduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, TaiwanSchool of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei City 112304, TaiwanDepartment of Obstetrics and Gynaecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanGraduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, TaiwanVulvovaginal candidiasis (VVC), a condition predominantly caused by <i>Candida albicans</i>, affects millions of women worldwide, prompting the need for alternative treatments due to the side effects and increasing resistance associated with conventional imidazole antifungals. This study investigated VAGINNE<sup>®</sup>, a novel fermentation broth derived from <i>Lactobacillus</i> species, as a potential VVC treatment. Using a BALB/c mouse model of <i>C. albicans</i> infection, we evaluated VAGINNE<sup>®</sup>’s effects on vaginal microbiome composition, inflammatory markers, and tissue integrity. Our findings revealed that VAGINNE<sup>®</sup> treatment enhanced the growth of beneficial <i>Lactobacillus</i> species while suppressing <i>C. albicans</i> proliferation, leading to a more balanced vaginal microbiome. Additionally, VAGINNE<sup>®</sup> significantly reduced pro-inflammatory cytokines (IL-17A, IL-22, IL-23) in vaginal tissues and systemic inflammatory markers (IL-6, IL-1β) in plasma. Histological analysis showed minimal fungal invasion and preserved vaginal epithelial integrity in VAGINNE<sup>®</sup>-treated mice compared to untreated controls. These results suggest that VAGINNE<sup>®</sup> could serve as an effective anti-Candida and anti-inflammatory agent for managing VVC, offering a promising alternative to traditional antifungal treatments. By promoting a healthy vaginal microbiome, reducing inflammation, and maintaining tissue health, this probiotic-based approach presents a novel strategy for addressing VVC, particularly in cases of drug resistance or adverse reactions to standard therapies. This study underscores the potential of microbiome-modulating strategies in managing vaginal infections, paving the way for more targeted and side-effect-free VVC treatments.https://www.mdpi.com/2309-608X/11/1/18vulvovaginal candidiasis (VVC)<i>Candida albicans</i><i>Lactobacillus</i>inflammationfermentation broth |
| spellingShingle | Huann-Cheng Horng Jin-Wei Xu Yi-Shan Kuo Yu-Sin Chen Yu-Hsuan Chiu Kuan-Hao Tsui Yu-Tang Tung Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of <i>Lactobacillus</i> Fermentation Broth in Treating Vulvovaginal Candidiasis Journal of Fungi vulvovaginal candidiasis (VVC) <i>Candida albicans</i> <i>Lactobacillus</i> inflammation fermentation broth |
| title | Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of <i>Lactobacillus</i> Fermentation Broth in Treating Vulvovaginal Candidiasis |
| title_full | Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of <i>Lactobacillus</i> Fermentation Broth in Treating Vulvovaginal Candidiasis |
| title_fullStr | Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of <i>Lactobacillus</i> Fermentation Broth in Treating Vulvovaginal Candidiasis |
| title_full_unstemmed | Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of <i>Lactobacillus</i> Fermentation Broth in Treating Vulvovaginal Candidiasis |
| title_short | Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of <i>Lactobacillus</i> Fermentation Broth in Treating Vulvovaginal Candidiasis |
| title_sort | dual mechanisms of action anti candida and anti inflammatory potential of i lactobacillus i fermentation broth in treating vulvovaginal candidiasis |
| topic | vulvovaginal candidiasis (VVC) <i>Candida albicans</i> <i>Lactobacillus</i> inflammation fermentation broth |
| url | https://www.mdpi.com/2309-608X/11/1/18 |
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