The hypertrophic cardiomyopathy-associated A331P actin variant enhances basal contractile activity and elicits resting muscle dysfunction

The hypertrophic cardiomyopathy-associated A331P actin variant enhances basal contractile activity and elicits resting muscle dysfunction

Summary: Previous studies aimed at defining the mechanistic basis of hypertrophic cardiomyopathy caused by A331P cardiac actin have reported conflicting results. The mutation is located along an actin surface strand, proximal to residues that interact with tropomyosin. These F-actin-tropomyosin asso...

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Bibliographic Details
Main Authors: Matthew H. Doran, Michael J. Rynkiewicz, Evan Despond, Meera C. Viswanathan, Aditi Madan, Kripa Chitre, Axel J. Fenwick, Duncan Sousa, William Lehman, John F. Dawson, Anthony Cammarato
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:iScience
Subjects:
Biological sciences
Cell biology
Molecular interaction
Molecular Structure
Structural biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225000768
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