Therapeutic effects of mirodenafil, a phosphodiesterase 5 inhibitor, on stroke models in rats

Therapeutic effects of mirodenafil, a phosphodiesterase 5 inhibitor, on stroke models in rats

Mirodenafil is a phosphodiesterase 5 (PDE5) inhibitor with high specificity for its target and good blood-brain barrier permeability. The drug, which is currently used for treatment of erectile dysfunction, reduces Aβ and pTau levels and improves cognitive function in mouse models of Alzheimer'...

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Bibliographic Details
Main Authors: Fred Kim, Padmanabh Singh, Hyunji Jo, Tianyang Xi, Dong-Keun Song, Sae Kwang Ku, Jai Jun Choung
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Neurotherapeutics
Subjects:
Middle cerebral artery occlusion (MCAO)
Mirodenafil
PDE5 inhibitor
Rats
Stroke
Online Access:http://www.sciencedirect.com/science/article/pii/S1878747924001508
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