O-GlcNAcylated FTO promotes m6A modification of SOX4 to enhance MDS/AML cell proliferation

O-GlcNAcylated FTO promotes m6A modification of SOX4 to enhance MDS/AML cell proliferation

Abstract Fat mass and obesity-associated protein (FTO) was the first m6A demethylase identified, which is responsible for eliminating m6A modifications in target RNAs. While it is well-established that numerous cytosolic and nuclear proteins undergo O-GlcNAcylation, the possibility of FTO being O-Gl...

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Bibliographic Details
Main Authors: Junjie Gou, Jingjing Bi, Kexin Wang, Lei Lei, Yanli Feng, Zengqi Tan, Jiaojiao Gao, Yanan Song, Enci Kang, Feng Guan, Xiang Li
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cell Communication and Signaling
Subjects:
Myelodysplastic syndromes (MDS)
Acute myeloid leukemia (AML)
O-linked N-acetyglucosamine (O-GlcNAc)
Fat mass and obesity-associated protein (FTO)
SRY related high mobility group box (SOX4)
Online Access:https://doi.org/10.1186/s12964-025-02058-6
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