In vivo efficacy of NRL knockdown with cell-penetrating siRNA in retinal degeneration

In vivo efficacy of NRL knockdown with cell-penetrating siRNA in retinal degeneration

Abstract Retinal degenerative diseases, such as retinitis pigmentosa (RP) and age‑related macular degeneration (AMD), lead to progressive vision loss through photoreceptor degeneration; RP begins with the gradual loss of peripheral rods, whereas AMD causes central‑vision loss mainly because macular...

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Main Authors: Hyungwoo Lee, Hyoik Jang, Jae-Byoung Chae, Hyo Kyung Lee, Chanok Son, Chul-Woo Park, Taejeong Ha, Munjeong Yum, Sungmi Park, Sun Woo Hong, Suk Young Lee, Jungmook Lyu, Semin Lee, Dong Ki Lee, Hyewon Chung
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-07299-6
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