Hypersensitivity Pneumonitis: Challenges of a Complex Disease
Hypersensitivity pneumonitis (HP) is a complex interstitial lung disease caused by chronic inhalation of a wide variety of antigens in susceptible and sensitized individuals, commonly associated with an occupational exposure. An impressive number of inciting antigens causing hypersensitivity pneumon...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2024/4919951 |
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| _version_ | 1832548341202812928 |
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| author | Diana Calaras Aliona David Eirini Vasarmidi Katerina Antoniou Alexandru Corlateanu |
| author_facet | Diana Calaras Aliona David Eirini Vasarmidi Katerina Antoniou Alexandru Corlateanu |
| author_sort | Diana Calaras |
| collection | DOAJ |
| description | Hypersensitivity pneumonitis (HP) is a complex interstitial lung disease caused by chronic inhalation of a wide variety of antigens in susceptible and sensitized individuals, commonly associated with an occupational exposure. An impressive number of inciting antigens causing hypersensitivity pneumonitis have been found to cover a wide range of occupations. As working practices have changed over time, especially in industrialized countries, new names for occupational HP have emerged. This review emphasizes the main diagnostic issues arising from the high variability of clinical presentation and the broad spectrum of causal antigens. Furthermore, it provides an overview of current methods to unveil possible causes of hypersensitivity pneumonitis, highlights HP’s current diagnostic and treatment challenges and the remaining areas of uncertainty, and presents prevention strategies. |
| format | Article |
| id | doaj-art-a00eef364d5d4625ae65071691a2f86e |
| institution | Kabale University |
| issn | 1916-7245 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-a00eef364d5d4625ae65071691a2f86e2025-02-03T06:14:53ZengWileyCanadian Respiratory Journal1916-72452024-01-01202410.1155/2024/4919951Hypersensitivity Pneumonitis: Challenges of a Complex DiseaseDiana Calaras0Aliona David1Eirini Vasarmidi2Katerina Antoniou3Alexandru Corlateanu4Department of Pulmonology and AllergologyOutpatient DepartmentDepartment of Respiratory MedicineDepartment of Respiratory MedicineDepartment of Pulmonology and AllergologyHypersensitivity pneumonitis (HP) is a complex interstitial lung disease caused by chronic inhalation of a wide variety of antigens in susceptible and sensitized individuals, commonly associated with an occupational exposure. An impressive number of inciting antigens causing hypersensitivity pneumonitis have been found to cover a wide range of occupations. As working practices have changed over time, especially in industrialized countries, new names for occupational HP have emerged. This review emphasizes the main diagnostic issues arising from the high variability of clinical presentation and the broad spectrum of causal antigens. Furthermore, it provides an overview of current methods to unveil possible causes of hypersensitivity pneumonitis, highlights HP’s current diagnostic and treatment challenges and the remaining areas of uncertainty, and presents prevention strategies.http://dx.doi.org/10.1155/2024/4919951 |
| spellingShingle | Diana Calaras Aliona David Eirini Vasarmidi Katerina Antoniou Alexandru Corlateanu Hypersensitivity Pneumonitis: Challenges of a Complex Disease Canadian Respiratory Journal |
| title | Hypersensitivity Pneumonitis: Challenges of a Complex Disease |
| title_full | Hypersensitivity Pneumonitis: Challenges of a Complex Disease |
| title_fullStr | Hypersensitivity Pneumonitis: Challenges of a Complex Disease |
| title_full_unstemmed | Hypersensitivity Pneumonitis: Challenges of a Complex Disease |
| title_short | Hypersensitivity Pneumonitis: Challenges of a Complex Disease |
| title_sort | hypersensitivity pneumonitis challenges of a complex disease |
| url | http://dx.doi.org/10.1155/2024/4919951 |
| work_keys_str_mv | AT dianacalaras hypersensitivitypneumonitischallengesofacomplexdisease AT alionadavid hypersensitivitypneumonitischallengesofacomplexdisease AT eirinivasarmidi hypersensitivitypneumonitischallengesofacomplexdisease AT katerinaantoniou hypersensitivitypneumonitischallengesofacomplexdisease AT alexandrucorlateanu hypersensitivitypneumonitischallengesofacomplexdisease |