Technologies to improve sperm retrieval in men undergoing micro-TESE for NOA

Nonobstructive azoospermia (NOA) is considered the most challenging clinical scenario for infertile men and current treatments leave many men unsuccessful at being able to achieve a pregnancy with their partner using their own sperm. Microdissection testicular sperm extraction (micro-TESE) is the ch...

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Bibliographic Details
Main Authors: Parviz K Kavoussi, Widi Atmoko, Germar-Michael Pinggera
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-05-01
Series:Asian Journal of Andrology
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Online Access:https://journals.lww.com/10.4103/aja202450
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Summary:Nonobstructive azoospermia (NOA) is considered the most challenging clinical scenario for infertile men and current treatments leave many men unsuccessful at being able to achieve a pregnancy with their partner using their own sperm. Microdissection testicular sperm extraction (micro-TESE) is the choice for men with NOA desiring to father children with their own gametes. Micro-TESE results in the highest numbers of sperm cells retrieved for use with in vitro fertilization/intracytoplasmic sperm injection. With suboptimal micro-TESE success rates of sperm retrieval and then pregnancy and live birth using the retrieved sperm with in vitro fertilization/intracytoplasmic sperm injection, advances to improve outcomes are necessary. This article comprehensively reviews the technologies investigated to date to improve the outcomes for men undergoing micro-TESE.
ISSN:1008-682X
1745-7262