Monte Carlo modeling of temporal point spread functions and sensitivity functions for mesoscopic time-resolved fluorescence molecular tomography
The paper describes a TurbidMC code that implements a perturbative Monte Carlo method to model temporal point spread functions and sensitivity functions for time-resolved fluorescence molecular tomography (FMT). The code is aimed at working with a particular FMT method published earlier (Ref. [22])...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Samara National Research University
2023-10-01
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| Series: | Компьютерная оптика |
| Subjects: | |
| Online Access: | https://www.computeroptics.ru/eng/KO/Annot/KO47-5/470501e.html |
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| Summary: | The paper describes a TurbidMC code that implements a perturbative Monte Carlo method to model temporal point spread functions and sensitivity functions for time-resolved fluorescence molecular tomography (FMT). The code is aimed at working with a particular FMT method published earlier (Ref. [22]) which defines the specificity of sensitivity function calculation. The method solves the inverse problem first for a generalized fluorescence parameter distribution function and then calculates separate distributions for the fluorophore absorption coefficient and the fluorescence lifetime. The proper operation of the code was verified through a comparison between fluorescence temporal point spread functions from test calculations and data from experiments where a phantom with a fluorophore was scanned with a three-channel probe in the mesoscopic reflectance regime. An example is given on the reconstruction of fluorescence parameter distributions. It shows that the sensitivity functions are calculated correctly. |
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| ISSN: | 0134-2452 2412-6179 |