Strategies for Regenerating Striatal Neurons in the Adult Brain by Using Endogenous Neural Stem Cells
Currently, there is no effective treatment for the marked neuronal loss caused by neurodegenerative diseases, such as Huntington's disease (HD) or ischemic stroke. However, recent studies have shown that new neurons are continuously generated by endogenous neural stem cells in the subventricula...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2011/898012 |
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| author | Kanako Nakaguchi Hiroshi Masuda Naoko Kaneko Kazunobu Sawamoto |
| author_facet | Kanako Nakaguchi Hiroshi Masuda Naoko Kaneko Kazunobu Sawamoto |
| author_sort | Kanako Nakaguchi |
| collection | DOAJ |
| description | Currently, there is no effective treatment for the marked neuronal loss caused by neurodegenerative diseases, such as Huntington's disease (HD) or ischemic stroke. However, recent studies have shown that new neurons are continuously generated by endogenous neural stem cells in the subventricular zone (SVZ) of the adult mammalian brain, including the human brain. Because some of these new neurons migrate to the injured striatum and differentiate into mature neurons, such new neurons may be able to replace degenerated neurons and improve or repair neurological deficits. To establish a neuroregenerative therapy using this endogenous system, endogenous regulatory mechanisms that can be co-opted for efficient regenerative interventions must be understood, along with any potential drawbacks. Here, we review current knowledge on the generation of new neurons in the adult brain and discuss their potential for use in replacing striatal neurons lost to neurodegenerative diseases, including HD, and to ischemic stroke. |
| format | Article |
| id | doaj-art-9ff1c15d66c844bf868466fbe62405d7 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-9ff1c15d66c844bf868466fbe62405d72025-02-03T01:21:52ZengWileyNeurology Research International2090-18522090-18602011-01-01201110.1155/2011/898012898012Strategies for Regenerating Striatal Neurons in the Adult Brain by Using Endogenous Neural Stem CellsKanako Nakaguchi0Hiroshi Masuda1Naoko Kaneko2Kazunobu Sawamoto3Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, JapanDepartment of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, JapanDepartment of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, JapanDepartment of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, JapanCurrently, there is no effective treatment for the marked neuronal loss caused by neurodegenerative diseases, such as Huntington's disease (HD) or ischemic stroke. However, recent studies have shown that new neurons are continuously generated by endogenous neural stem cells in the subventricular zone (SVZ) of the adult mammalian brain, including the human brain. Because some of these new neurons migrate to the injured striatum and differentiate into mature neurons, such new neurons may be able to replace degenerated neurons and improve or repair neurological deficits. To establish a neuroregenerative therapy using this endogenous system, endogenous regulatory mechanisms that can be co-opted for efficient regenerative interventions must be understood, along with any potential drawbacks. Here, we review current knowledge on the generation of new neurons in the adult brain and discuss their potential for use in replacing striatal neurons lost to neurodegenerative diseases, including HD, and to ischemic stroke.http://dx.doi.org/10.1155/2011/898012 |
| spellingShingle | Kanako Nakaguchi Hiroshi Masuda Naoko Kaneko Kazunobu Sawamoto Strategies for Regenerating Striatal Neurons in the Adult Brain by Using Endogenous Neural Stem Cells Neurology Research International |
| title | Strategies for Regenerating Striatal Neurons in the Adult Brain by Using Endogenous Neural Stem Cells |
| title_full | Strategies for Regenerating Striatal Neurons in the Adult Brain by Using Endogenous Neural Stem Cells |
| title_fullStr | Strategies for Regenerating Striatal Neurons in the Adult Brain by Using Endogenous Neural Stem Cells |
| title_full_unstemmed | Strategies for Regenerating Striatal Neurons in the Adult Brain by Using Endogenous Neural Stem Cells |
| title_short | Strategies for Regenerating Striatal Neurons in the Adult Brain by Using Endogenous Neural Stem Cells |
| title_sort | strategies for regenerating striatal neurons in the adult brain by using endogenous neural stem cells |
| url | http://dx.doi.org/10.1155/2011/898012 |
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