Anti-tumor role and molecular mechanism of vanillic acid
Abstract Vanillic Acid (VA) is an aromatic acid extracted from traditional Chinese medicine such as Angelica sinensis and Panax ginseng, which has demonstrated potent anti-cancer activity, inhibiting the onset and progression of various malignant tumors. This review highlights the principal mechanis...
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01746-6 |
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| author | Xunxing Hao Zhixiao Gao Mingzhe Hu |
| author_facet | Xunxing Hao Zhixiao Gao Mingzhe Hu |
| author_sort | Xunxing Hao |
| collection | DOAJ |
| description | Abstract Vanillic Acid (VA) is an aromatic acid extracted from traditional Chinese medicine such as Angelica sinensis and Panax ginseng, which has demonstrated potent anti-cancer activity, inhibiting the onset and progression of various malignant tumors. This review highlights the principal mechanism by which VA exerts its anticancer activity, including apoptosis induction, specifically promoting the generation of intracellular reactive oxygen species (ROS), which in turn triggers mitochondrial apoptosis. Furthermore, VA disrupts the cancer cell cycle, arresting most cancer cells at the G1 phase, curtails cell migration, invasion, angiogenesis, and potentiates the therapeutic efficacy of chemotherapeutic drugs, all while minimizing adverse reactions. This paper offers a comprehensive review of VA's anti-tumor effects and underlying mechanisms, aiming to provide some references for scientists and clinical physicians in the research of anti-tumor therapeutic strategies. |
| format | Article |
| id | doaj-art-9fe8157a1cdf4c5ba2b49b19a0e7f19a |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-9fe8157a1cdf4c5ba2b49b19a0e7f19a2025-01-19T12:29:19ZengSpringerDiscover Oncology2730-60112025-01-0116111310.1007/s12672-025-01746-6Anti-tumor role and molecular mechanism of vanillic acidXunxing Hao0Zhixiao Gao1Mingzhe Hu2Department of Traditional Chinese Medicine, Shandong University of Traditional Chinese MedicineInstitute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese MedicineAbstract Vanillic Acid (VA) is an aromatic acid extracted from traditional Chinese medicine such as Angelica sinensis and Panax ginseng, which has demonstrated potent anti-cancer activity, inhibiting the onset and progression of various malignant tumors. This review highlights the principal mechanism by which VA exerts its anticancer activity, including apoptosis induction, specifically promoting the generation of intracellular reactive oxygen species (ROS), which in turn triggers mitochondrial apoptosis. Furthermore, VA disrupts the cancer cell cycle, arresting most cancer cells at the G1 phase, curtails cell migration, invasion, angiogenesis, and potentiates the therapeutic efficacy of chemotherapeutic drugs, all while minimizing adverse reactions. This paper offers a comprehensive review of VA's anti-tumor effects and underlying mechanisms, aiming to provide some references for scientists and clinical physicians in the research of anti-tumor therapeutic strategies.https://doi.org/10.1007/s12672-025-01746-6Vanillic acidAnti-tumorMolecular mechanism |
| spellingShingle | Xunxing Hao Zhixiao Gao Mingzhe Hu Anti-tumor role and molecular mechanism of vanillic acid Discover Oncology Vanillic acid Anti-tumor Molecular mechanism |
| title | Anti-tumor role and molecular mechanism of vanillic acid |
| title_full | Anti-tumor role and molecular mechanism of vanillic acid |
| title_fullStr | Anti-tumor role and molecular mechanism of vanillic acid |
| title_full_unstemmed | Anti-tumor role and molecular mechanism of vanillic acid |
| title_short | Anti-tumor role and molecular mechanism of vanillic acid |
| title_sort | anti tumor role and molecular mechanism of vanillic acid |
| topic | Vanillic acid Anti-tumor Molecular mechanism |
| url | https://doi.org/10.1007/s12672-025-01746-6 |
| work_keys_str_mv | AT xunxinghao antitumorroleandmolecularmechanismofvanillicacid AT zhixiaogao antitumorroleandmolecularmechanismofvanillicacid AT mingzhehu antitumorroleandmolecularmechanismofvanillicacid |