Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosis
BackgroundSepsis, characterized by a dysregulated host response to infection, often leads to organ dysfunction, and vascular endothelial dysfunction plays a central role. The erythropoietin-producing hepatocellular carcinoma (Eph)A2 receptor is associated with increased vascular permeability; howeve...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1505882/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589928711585792 |
|---|---|
| author | Eun Hye Lee Mi Hwa Shin Se Hyun Kwak Ji Soo Choi Ah Young Leem Su Hwan Lee Kyung Soo Chung Young Sam Kim Sang-Guk Lee Moo Suk Park |
| author_facet | Eun Hye Lee Mi Hwa Shin Se Hyun Kwak Ji Soo Choi Ah Young Leem Su Hwan Lee Kyung Soo Chung Young Sam Kim Sang-Guk Lee Moo Suk Park |
| author_sort | Eun Hye Lee |
| collection | DOAJ |
| description | BackgroundSepsis, characterized by a dysregulated host response to infection, often leads to organ dysfunction, and vascular endothelial dysfunction plays a central role. The erythropoietin-producing hepatocellular carcinoma (Eph)A2 receptor is associated with increased vascular permeability; however, the developmental endothelial locus-1 (Del-1), has contrasting effects on endothelial function. Hence, we examined their potential as biomarkers of sepsis.MethodsIn total, 117 participants, including 20 healthy controls, 21 patients with systemic inflammatory response syndrome (SIRS), and 76 patients with sepsis, were enrolled in this study. Sepsis severity was assessed using the Acute Physiology and Chronic Health Evaluation (APACHE) II and the Sequential Organ Failure Assessment (SOFA) scores.ResultsThe Median plasma EphA2 levels increased progressively from healthy controls to SIRS and sepsis cases (154.29, 293.52, and 554.24 pg/mL; all p < 0.05). The median plasma Del-1 levels were highest in healthy controls, lowest in SIRS, and intermediate level in sepsis (101.27, 16.88, and 36.9 pg/mL; all p < 0.001). The levels of both biomarkers were higher in 28-day non-survivors than in survivors, in patients with sepsis (EphA2:898.09 vs. 475.88 pg/mL, p < 0.001; Del-1:46.09 vs. 32.68 pg/mL, p = 0.193); however, only EphA2 was statistically significant. The area under the curve for the EphA2 was 0.74 in the receiver operating characteristic curve analysis for predicting 28-day mortality, whereas APACHE II, SOFA, and Del-1 showed values of 0.762, 0.614, and 0.595, respectively. Kaplan–Meier analysis using these cutoffs revealed that survival was significantly higher in the group with both low EphA2 and Del-1 levels compared to the group with high levels of both markers (p < 0.001).ConclusionPlasma EphA2 levels consistently increased with sepsis severity, suggesting its biomarker value for sepsis diagnosis and prognosis. In contrast, plasma Del-1 response was variable, indicating its limited prognostic utility. |
| format | Article |
| id | doaj-art-9fe803b00c8a4c58adecf25e84036ae3 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-9fe803b00c8a4c58adecf25e84036ae32025-01-24T05:21:20ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011210.3389/fmed.2025.15058821505882Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosisEun Hye Lee0Mi Hwa Shin1Se Hyun Kwak2Ji Soo Choi3Ah Young Leem4Su Hwan Lee5Kyung Soo Chung6Young Sam Kim7Sang-Guk Lee8Moo Suk Park9Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Institute of Chest Diseases, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of KoreaDivision of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of KoreaDivision of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Institute of Chest Diseases, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Institute of Chest Diseases, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Institute of Chest Diseases, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Institute of Chest Diseases, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of KoreaDepartment of Laboratory Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Institute of Chest Diseases, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of KoreaBackgroundSepsis, characterized by a dysregulated host response to infection, often leads to organ dysfunction, and vascular endothelial dysfunction plays a central role. The erythropoietin-producing hepatocellular carcinoma (Eph)A2 receptor is associated with increased vascular permeability; however, the developmental endothelial locus-1 (Del-1), has contrasting effects on endothelial function. Hence, we examined their potential as biomarkers of sepsis.MethodsIn total, 117 participants, including 20 healthy controls, 21 patients with systemic inflammatory response syndrome (SIRS), and 76 patients with sepsis, were enrolled in this study. Sepsis severity was assessed using the Acute Physiology and Chronic Health Evaluation (APACHE) II and the Sequential Organ Failure Assessment (SOFA) scores.ResultsThe Median plasma EphA2 levels increased progressively from healthy controls to SIRS and sepsis cases (154.29, 293.52, and 554.24 pg/mL; all p < 0.05). The median plasma Del-1 levels were highest in healthy controls, lowest in SIRS, and intermediate level in sepsis (101.27, 16.88, and 36.9 pg/mL; all p < 0.001). The levels of both biomarkers were higher in 28-day non-survivors than in survivors, in patients with sepsis (EphA2:898.09 vs. 475.88 pg/mL, p < 0.001; Del-1:46.09 vs. 32.68 pg/mL, p = 0.193); however, only EphA2 was statistically significant. The area under the curve for the EphA2 was 0.74 in the receiver operating characteristic curve analysis for predicting 28-day mortality, whereas APACHE II, SOFA, and Del-1 showed values of 0.762, 0.614, and 0.595, respectively. Kaplan–Meier analysis using these cutoffs revealed that survival was significantly higher in the group with both low EphA2 and Del-1 levels compared to the group with high levels of both markers (p < 0.001).ConclusionPlasma EphA2 levels consistently increased with sepsis severity, suggesting its biomarker value for sepsis diagnosis and prognosis. In contrast, plasma Del-1 response was variable, indicating its limited prognostic utility.https://www.frontiersin.org/articles/10.3389/fmed.2025.1505882/fullEphA2Del-1sepsisbiomarkerdiagnosisprognosis |
| spellingShingle | Eun Hye Lee Mi Hwa Shin Se Hyun Kwak Ji Soo Choi Ah Young Leem Su Hwan Lee Kyung Soo Chung Young Sam Kim Sang-Guk Lee Moo Suk Park Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosis Frontiers in Medicine EphA2 Del-1 sepsis biomarker diagnosis prognosis |
| title | Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosis |
| title_full | Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosis |
| title_fullStr | Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosis |
| title_full_unstemmed | Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosis |
| title_short | Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosis |
| title_sort | plasma epha2 level is a superior biomarker to del 1 for sepsis diagnosis and prognosis |
| topic | EphA2 Del-1 sepsis biomarker diagnosis prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1505882/full |
| work_keys_str_mv | AT eunhyelee plasmaepha2levelisasuperiorbiomarkertodel1forsepsisdiagnosisandprognosis AT mihwashin plasmaepha2levelisasuperiorbiomarkertodel1forsepsisdiagnosisandprognosis AT sehyunkwak plasmaepha2levelisasuperiorbiomarkertodel1forsepsisdiagnosisandprognosis AT jisoochoi plasmaepha2levelisasuperiorbiomarkertodel1forsepsisdiagnosisandprognosis AT ahyoungleem plasmaepha2levelisasuperiorbiomarkertodel1forsepsisdiagnosisandprognosis AT suhwanlee plasmaepha2levelisasuperiorbiomarkertodel1forsepsisdiagnosisandprognosis AT kyungsoochung plasmaepha2levelisasuperiorbiomarkertodel1forsepsisdiagnosisandprognosis AT youngsamkim plasmaepha2levelisasuperiorbiomarkertodel1forsepsisdiagnosisandprognosis AT sangguklee plasmaepha2levelisasuperiorbiomarkertodel1forsepsisdiagnosisandprognosis AT moosukpark plasmaepha2levelisasuperiorbiomarkertodel1forsepsisdiagnosisandprognosis |