The Neutrophil to Lymphocyte Ratio and Other Full Blood Count Indices in Retinal Diseases: A Systematic Review of the Literature
<i>Background and Objectives:</i> The neutrophil to lymphocyte ratio (NLR) and other full blood count indices have been used as a marker of inflammation in a variety of diseases. The aim of the current review is to summarize the existing knowledge on the use of these indices in retinal d...
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2025-01-01
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| author | Dimitrios Kazantzis Genovefa Machairoudia Panagiotis Theodossiadis Irini Chatziralli |
| author_facet | Dimitrios Kazantzis Genovefa Machairoudia Panagiotis Theodossiadis Irini Chatziralli |
| author_sort | Dimitrios Kazantzis |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> The neutrophil to lymphocyte ratio (NLR) and other full blood count indices have been used as a marker of inflammation in a variety of diseases. The aim of the current review is to summarize the existing knowledge on the use of these indices in retinal diseases. <i>Materials and Methods:</i> A systematic review of the literature was conducted to find eligible articles. The PUBMED and Scopus databases were systematically searched for relevant studies examining full blood count indices in retinal diseases. <i>Results</i>: The NLR was elevated in a number of vitreoretinal conditions, such as wet age-related macular degeneration (AMD), diabetic retinopathy and retinal vein occlusion, compared to controls. Full blood count indices could be useful in predicting the response to anti-VEG treatment in patients with wet AMD or diabetic macular edema (DME). <i>Conclusions</i>: The NLR and other indices can be used as diagnostic markers in retinal diseases and as prognostic factors of the response to treatment. The small sample size and short follow-up of the included studies and the variation in the measurement and cutoffs used for the NLR are limitations of its use in retinal conditions. Future studies need to further validate these findings and try to establish a link between these ratios and retinal phenotypes. |
| format | Article |
| id | doaj-art-9fe70fc0721046889aa90ee3d681e78a |
| institution | Kabale University |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj-art-9fe70fc0721046889aa90ee3d681e78a2025-01-24T13:40:43ZengMDPI AGMedicina1010-660X1648-91442025-01-0161112510.3390/medicina61010125The Neutrophil to Lymphocyte Ratio and Other Full Blood Count Indices in Retinal Diseases: A Systematic Review of the LiteratureDimitrios Kazantzis0Genovefa Machairoudia1Panagiotis Theodossiadis2Irini Chatziralli32nd Department of Ophthalmology, Attikon Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece2nd Department of Ophthalmology, Attikon Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece2nd Department of Ophthalmology, Attikon Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece2nd Department of Ophthalmology, Attikon Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece<i>Background and Objectives:</i> The neutrophil to lymphocyte ratio (NLR) and other full blood count indices have been used as a marker of inflammation in a variety of diseases. The aim of the current review is to summarize the existing knowledge on the use of these indices in retinal diseases. <i>Materials and Methods:</i> A systematic review of the literature was conducted to find eligible articles. The PUBMED and Scopus databases were systematically searched for relevant studies examining full blood count indices in retinal diseases. <i>Results</i>: The NLR was elevated in a number of vitreoretinal conditions, such as wet age-related macular degeneration (AMD), diabetic retinopathy and retinal vein occlusion, compared to controls. Full blood count indices could be useful in predicting the response to anti-VEG treatment in patients with wet AMD or diabetic macular edema (DME). <i>Conclusions</i>: The NLR and other indices can be used as diagnostic markers in retinal diseases and as prognostic factors of the response to treatment. The small sample size and short follow-up of the included studies and the variation in the measurement and cutoffs used for the NLR are limitations of its use in retinal conditions. Future studies need to further validate these findings and try to establish a link between these ratios and retinal phenotypes.https://www.mdpi.com/1648-9144/61/1/125neutrophil to lymphocyte ratiocomplete blood countage-related macular degenerationdiabetic retinopathyretinal vein occlusion |
| spellingShingle | Dimitrios Kazantzis Genovefa Machairoudia Panagiotis Theodossiadis Irini Chatziralli The Neutrophil to Lymphocyte Ratio and Other Full Blood Count Indices in Retinal Diseases: A Systematic Review of the Literature Medicina neutrophil to lymphocyte ratio complete blood count age-related macular degeneration diabetic retinopathy retinal vein occlusion |
| title | The Neutrophil to Lymphocyte Ratio and Other Full Blood Count Indices in Retinal Diseases: A Systematic Review of the Literature |
| title_full | The Neutrophil to Lymphocyte Ratio and Other Full Blood Count Indices in Retinal Diseases: A Systematic Review of the Literature |
| title_fullStr | The Neutrophil to Lymphocyte Ratio and Other Full Blood Count Indices in Retinal Diseases: A Systematic Review of the Literature |
| title_full_unstemmed | The Neutrophil to Lymphocyte Ratio and Other Full Blood Count Indices in Retinal Diseases: A Systematic Review of the Literature |
| title_short | The Neutrophil to Lymphocyte Ratio and Other Full Blood Count Indices in Retinal Diseases: A Systematic Review of the Literature |
| title_sort | neutrophil to lymphocyte ratio and other full blood count indices in retinal diseases a systematic review of the literature |
| topic | neutrophil to lymphocyte ratio complete blood count age-related macular degeneration diabetic retinopathy retinal vein occlusion |
| url | https://www.mdpi.com/1648-9144/61/1/125 |
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