Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia
Objective. Systematic review and meta-analysis to observe the efficacy and safety of stem cell transplantation therapy in patients with brain ischemia. Methods. We searched Cochrane Library, PubMed, Ovid, CBM, CNKI, WanFang, and VIP Data from its inception to December 2015, to collect randomized con...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/6129579 |
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| _version_ | 1832564214299885568 |
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| author | Lukui Chen Guilong Zhang Ahsan Ali Khan Xiaoyuan Guo Yuchun Gu |
| author_facet | Lukui Chen Guilong Zhang Ahsan Ali Khan Xiaoyuan Guo Yuchun Gu |
| author_sort | Lukui Chen |
| collection | DOAJ |
| description | Objective. Systematic review and meta-analysis to observe the efficacy and safety of stem cell transplantation therapy in patients with brain ischemia. Methods. We searched Cochrane Library, PubMed, Ovid, CBM, CNKI, WanFang, and VIP Data from its inception to December 2015, to collect randomized controlled trials (RCT) of stem cell transplantation for the ischemic stroke. Two authors independently screened the literature according to the inclusion and exclusion criteria, extracted data, and assessed the risk of bias. Thereafter, meta-analysis was performed. Results. Sixteen studies and eighteen independent treatments were included in the current meta-analysis. The results based upon the pooled mean difference from baseline to follow-up points showed that the stem cell transplantation group was superior to the control group with statistical significance in the neurologic deficits score (NIHSS, MD = 1.57; 95% CI, 0.64–2.51; I2=57%; p=0.001), motor function (FMA, MD = 4.23; 95% CI, 3.08–5.38; I2=0%; p<0.00001), daily life ability (Barthel, MD = 8.37; 95% CI, 4.83–11.91; I2=63%; p<0.00001), and functional independence (FIM, MD = 8.89; 95% CI, 4.70–13.08; I2=79%; p<0.0001). Conclusions. It is suggested that the stem cell transplantation therapy for patients with brain ischemic stroke can significantly improve the neurological deficits and daily life quality, with no serious adverse events. However, higher quality and larger data studies are required for further investigation to support clinical application of stem cell transplantation. |
| format | Article |
| id | doaj-art-9fe06d79e88345ad8f2bf679defc2fbd |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-9fe06d79e88345ad8f2bf679defc2fbd2025-02-03T01:11:30ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/61295796129579Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain IschemiaLukui Chen0Guilong Zhang1Ahsan Ali Khan2Xiaoyuan Guo3Yuchun Gu4Department of Neurosurgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, ChinaDepartment of Neurosurgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, ChinaDepartment of Neurosurgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, ChinaDepartment of Neurosurgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, ChinaAston Institute of Regenerative Medicine, Aston Medical School, Aston University, Birmingham, UKObjective. Systematic review and meta-analysis to observe the efficacy and safety of stem cell transplantation therapy in patients with brain ischemia. Methods. We searched Cochrane Library, PubMed, Ovid, CBM, CNKI, WanFang, and VIP Data from its inception to December 2015, to collect randomized controlled trials (RCT) of stem cell transplantation for the ischemic stroke. Two authors independently screened the literature according to the inclusion and exclusion criteria, extracted data, and assessed the risk of bias. Thereafter, meta-analysis was performed. Results. Sixteen studies and eighteen independent treatments were included in the current meta-analysis. The results based upon the pooled mean difference from baseline to follow-up points showed that the stem cell transplantation group was superior to the control group with statistical significance in the neurologic deficits score (NIHSS, MD = 1.57; 95% CI, 0.64–2.51; I2=57%; p=0.001), motor function (FMA, MD = 4.23; 95% CI, 3.08–5.38; I2=0%; p<0.00001), daily life ability (Barthel, MD = 8.37; 95% CI, 4.83–11.91; I2=63%; p<0.00001), and functional independence (FIM, MD = 8.89; 95% CI, 4.70–13.08; I2=79%; p<0.0001). Conclusions. It is suggested that the stem cell transplantation therapy for patients with brain ischemic stroke can significantly improve the neurological deficits and daily life quality, with no serious adverse events. However, higher quality and larger data studies are required for further investigation to support clinical application of stem cell transplantation.http://dx.doi.org/10.1155/2016/6129579 |
| spellingShingle | Lukui Chen Guilong Zhang Ahsan Ali Khan Xiaoyuan Guo Yuchun Gu Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia Stem Cells International |
| title | Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia |
| title_full | Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia |
| title_fullStr | Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia |
| title_full_unstemmed | Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia |
| title_short | Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia |
| title_sort | clinical efficacy and meta analysis of stem cell therapies for patients with brain ischemia |
| url | http://dx.doi.org/10.1155/2016/6129579 |
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