The impact of innate immune response on the efficacy of oncolytic viruses
Oncolytic viruses represent a promising class of immunotherapeutic agents for the treatment of malignant tumors. The proposed mechanism of action of various oncolytic viruses has initially been explained by the ability of such viruses to selectively lyse tumor cells without damaging healthy ones. Re...
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| Format: | Article |
| Language: | English |
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Central Research Institute for Epidemiology
2024-12-01
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| Series: | Вопросы вирусологии |
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| Online Access: | https://virusjour.crie.ru/jour/article/viewFile/16692/939 |
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| author | Kirill N. Trachuk Nikolai B. Pestov Yulia K. Biryukova Nadezhda M. Kolyasnikova |
| author_facet | Kirill N. Trachuk Nikolai B. Pestov Yulia K. Biryukova Nadezhda M. Kolyasnikova |
| author_sort | Kirill N. Trachuk |
| collection | DOAJ |
| description | Oncolytic viruses represent a promising class of immunotherapeutic agents for the treatment of malignant tumors. The proposed mechanism of action of various oncolytic viruses has initially been explained by the ability of such viruses to selectively lyse tumor cells without damaging healthy ones. Recently, there have emerged more studies determining the effect of the antiviral immunostimulating mechanisms on the effectiveness of treatment in cancer patients. Stimulation of innate immune cells by an oncolytic virus can initiate an adaptive antitumor immune response, yet at the same time, the antiviral mechanisms of the immune system can limit the spread of the virus, thereby reducing its effectiveness. Thus, the success of the clinical application of the oncolytic viruses directly depends on the three key components: tumor immunosuppression, antiviral responses, and antitumor immune responses.
The review presents current data on the influence of pattern recognition receptors on the effectiveness of oncolytic viruses. |
| format | Article |
| id | doaj-art-9fd8cf9fdded445eb1891b84b9d724ef |
| institution | Kabale University |
| issn | 0507-4088 2411-2097 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Вопросы вирусологии |
| spelling | doaj-art-9fd8cf9fdded445eb1891b84b9d724ef2025-01-22T15:18:43ZengCentral Research Institute for EpidemiologyВопросы вирусологии0507-40882411-20972024-12-0169647948810.36233/0507-4088-2751251The impact of innate immune response on the efficacy of oncolytic virusesKirill N. Trachuk0https://orcid.org/0000-0002-2061-0274Nikolai B. Pestov1https://orcid.org/0000-0002-9973-0120Yulia K. Biryukova2https://orcid.org/0000-0002-5804-4001Nadezhda M. Kolyasnikova3https://orcid.org/0000-0002-9934-2582Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis)Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis)Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis)Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis)Oncolytic viruses represent a promising class of immunotherapeutic agents for the treatment of malignant tumors. The proposed mechanism of action of various oncolytic viruses has initially been explained by the ability of such viruses to selectively lyse tumor cells without damaging healthy ones. Recently, there have emerged more studies determining the effect of the antiviral immunostimulating mechanisms on the effectiveness of treatment in cancer patients. Stimulation of innate immune cells by an oncolytic virus can initiate an adaptive antitumor immune response, yet at the same time, the antiviral mechanisms of the immune system can limit the spread of the virus, thereby reducing its effectiveness. Thus, the success of the clinical application of the oncolytic viruses directly depends on the three key components: tumor immunosuppression, antiviral responses, and antitumor immune responses. The review presents current data on the influence of pattern recognition receptors on the effectiveness of oncolytic viruses.https://virusjour.crie.ru/jour/article/viewFile/16692/939reviewoncolytic virusesthe innate immune responseprrs |
| spellingShingle | Kirill N. Trachuk Nikolai B. Pestov Yulia K. Biryukova Nadezhda M. Kolyasnikova The impact of innate immune response on the efficacy of oncolytic viruses Вопросы вирусологии review oncolytic viruses the innate immune response prrs |
| title | The impact of innate immune response on the efficacy of oncolytic viruses |
| title_full | The impact of innate immune response on the efficacy of oncolytic viruses |
| title_fullStr | The impact of innate immune response on the efficacy of oncolytic viruses |
| title_full_unstemmed | The impact of innate immune response on the efficacy of oncolytic viruses |
| title_short | The impact of innate immune response on the efficacy of oncolytic viruses |
| title_sort | impact of innate immune response on the efficacy of oncolytic viruses |
| topic | review oncolytic viruses the innate immune response prrs |
| url | https://virusjour.crie.ru/jour/article/viewFile/16692/939 |
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