Meta-Analysis of Visual Evoked Potential and Parkinson’s Disease
Background. Previous studies suggested that visual evoked potential (VEP) was impaired in patients with Parkinson’s disease (PD), but the results were inconsistent. Methods. We conducted a systematic review and meta-analysis to explore whether the VEP was significantly different between PD patients...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2018/3201308 |
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| _version_ | 1832550645853323264 |
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| author | Song-bin He Chun-yan Liu Lin-di Chen Zhi-nan Ye Ya-ping Zhang Wei-guo Tang Bin-da Wang Xiang Gao |
| author_facet | Song-bin He Chun-yan Liu Lin-di Chen Zhi-nan Ye Ya-ping Zhang Wei-guo Tang Bin-da Wang Xiang Gao |
| author_sort | Song-bin He |
| collection | DOAJ |
| description | Background. Previous studies suggested that visual evoked potential (VEP) was impaired in patients with Parkinson’s disease (PD), but the results were inconsistent. Methods. We conducted a systematic review and meta-analysis to explore whether the VEP was significantly different between PD patients and healthy controls. Case-control studies of PD were selected through an electronic search of the databases PubMed, Embase, and the Cochrane Central Register of Controlled Trials. We calculated the pooled weighted mean differences (WMDs) and 95% confidence intervals (CIs) between individuals with PD and controls using the random-effects model. Results. Twenty case-control studies which met our inclusion criteria were included in the final meta-analysis. We found that the P100 latency in PD was significantly higher compared with healthy controls (pooled WMD = 6.04, 95% CI: 2.73 to 9.35, P=0.0003, n=20). However, the difference in the mean amplitude of P100 was not significant between the two groups (pooled WMD = 0.64, 95% CI: −0.06 to 1.33, P=0.07) based on 10 studies with the P100 amplitude values available. Conclusions. The higher P100 latency of VEP was observed in PD patients, relative to healthy controls. Our findings suggest that electrophysiological changes and functional defect in the visual pathway of PD patients are important to our understanding of the pathophysiology of visual involvement in PD. |
| format | Article |
| id | doaj-art-9fd6053db32c4496b34b18661896c945 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-9fd6053db32c4496b34b18661896c9452025-02-03T06:06:11ZengWileyParkinson's Disease2090-80832042-00802018-01-01201810.1155/2018/32013083201308Meta-Analysis of Visual Evoked Potential and Parkinson’s DiseaseSong-bin He0Chun-yan Liu1Lin-di Chen2Zhi-nan Ye3Ya-ping Zhang4Wei-guo Tang5Bin-da Wang6Xiang Gao7Department of Neurology, Zhoushan Hospital, Wenzhou Medical University, Zhoushan 316021, ChinaDepartment of Critical Care Medicine, Huzhou Central Hospital, Huzhou 313000, ChinaDepartment of Neurology, Zhoushan Hospital, Wenzhou Medical University, Zhoushan 316021, ChinaDepartment of Neurology, Taizhou Municipal Hospital, Taizhou 318000, ChinaDepartment of Neurology, Taizhou Municipal Hospital, Taizhou 318000, ChinaDepartment of Neurology, Zhoushan Hospital, Wenzhou Medical University, Zhoushan 316021, ChinaDepartment of Neurology, Zhoushan Hospital, Wenzhou Medical University, Zhoushan 316021, ChinaDepartment of Nutritional Sciences, The Pennsylvania State University, USABackground. Previous studies suggested that visual evoked potential (VEP) was impaired in patients with Parkinson’s disease (PD), but the results were inconsistent. Methods. We conducted a systematic review and meta-analysis to explore whether the VEP was significantly different between PD patients and healthy controls. Case-control studies of PD were selected through an electronic search of the databases PubMed, Embase, and the Cochrane Central Register of Controlled Trials. We calculated the pooled weighted mean differences (WMDs) and 95% confidence intervals (CIs) between individuals with PD and controls using the random-effects model. Results. Twenty case-control studies which met our inclusion criteria were included in the final meta-analysis. We found that the P100 latency in PD was significantly higher compared with healthy controls (pooled WMD = 6.04, 95% CI: 2.73 to 9.35, P=0.0003, n=20). However, the difference in the mean amplitude of P100 was not significant between the two groups (pooled WMD = 0.64, 95% CI: −0.06 to 1.33, P=0.07) based on 10 studies with the P100 amplitude values available. Conclusions. The higher P100 latency of VEP was observed in PD patients, relative to healthy controls. Our findings suggest that electrophysiological changes and functional defect in the visual pathway of PD patients are important to our understanding of the pathophysiology of visual involvement in PD.http://dx.doi.org/10.1155/2018/3201308 |
| spellingShingle | Song-bin He Chun-yan Liu Lin-di Chen Zhi-nan Ye Ya-ping Zhang Wei-guo Tang Bin-da Wang Xiang Gao Meta-Analysis of Visual Evoked Potential and Parkinson’s Disease Parkinson's Disease |
| title | Meta-Analysis of Visual Evoked Potential and Parkinson’s Disease |
| title_full | Meta-Analysis of Visual Evoked Potential and Parkinson’s Disease |
| title_fullStr | Meta-Analysis of Visual Evoked Potential and Parkinson’s Disease |
| title_full_unstemmed | Meta-Analysis of Visual Evoked Potential and Parkinson’s Disease |
| title_short | Meta-Analysis of Visual Evoked Potential and Parkinson’s Disease |
| title_sort | meta analysis of visual evoked potential and parkinson s disease |
| url | http://dx.doi.org/10.1155/2018/3201308 |
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