Functional Characterization of the SHIP1-Domains Regarding Their Contribution to Inositol 5-Phosphatase Activity

Functional Characterization of the SHIP1-Domains Regarding Their Contribution to Inositol 5-Phosphatase Activity

The Src homology 2 domain-containing inositol 5-phosphatase 1 (SHIP1) is a multidomain protein consisting of two protein–protein interaction domains, the Src homology 2 (SH2) domain, and the proline-rich region (PRR), as well as three phosphoinositide-binding domains, the pleckstrin homology-like (P...

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Bibliographic Details
Main Authors: Spike Murphy Müller, Nina Nelson, Manfred Jücker
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Biomolecules
Subjects:
SHIP1
phosphatidylinositol phosphatase
phosphatidylinositide 3-kinase (PI 3-kinase)
AKT (=PKB)
PI3K/AKT signaling pathway
phosphatase activity
Online Access:https://www.mdpi.com/2218-273X/15/1/105
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