Renal Cancer Stem Cells: Characterization and Targeted Therapies
Renal cell carcinoma (RCC) is a major neoplasm with high incidence in western countries. Tumors are heterogeneous and are composed of differentiated cancer cells, stromal cells, and cancer stem cells (CSCs). CSCs possess two main properties: self-renewal and proliferation. Additionally, they can gen...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/8342625 |
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| _version_ | 1832568306502991872 |
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| author | Anna Julie Peired Alessandro Sisti Paola Romagnani |
| author_facet | Anna Julie Peired Alessandro Sisti Paola Romagnani |
| author_sort | Anna Julie Peired |
| collection | DOAJ |
| description | Renal cell carcinoma (RCC) is a major neoplasm with high incidence in western countries. Tumors are heterogeneous and are composed of differentiated cancer cells, stromal cells, and cancer stem cells (CSCs). CSCs possess two main properties: self-renewal and proliferation. Additionally, they can generate new tumors once transplanted into immunodeficient mice. Several approaches have been described to identify them, through the expression of cell markers, functional assays, or a combination of both. As CSCs are involved in the resistance mechanisms to radio- and chemotherapies, several new strategies have been proposed to directly target CSCs in RCC. One approach drives CSCs to differentiate into cancer cells sensitive to conventional treatments, while the other proposes to eradicate them selectively. A series of innovative therapies aiming at eliminating CSCs have been designed to treat other types of cancer and have not been experimented with on RCC yet, but they reveal themselves to be promising. In conclusion, CSCs are an important player in carcinogenesis and represent a valid target for therapy in RCC patients. |
| format | Article |
| id | doaj-art-9fcf23ffc97d4a59a1932f37cfc64d7e |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-9fcf23ffc97d4a59a1932f37cfc64d7e2025-02-03T00:59:20ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/83426258342625Renal Cancer Stem Cells: Characterization and Targeted TherapiesAnna Julie Peired0Alessandro Sisti1Paola Romagnani2Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies (DENOTHE), 50139 Florence, ItalyExcellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies (DENOTHE), 50139 Florence, ItalyExcellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies (DENOTHE), 50139 Florence, ItalyRenal cell carcinoma (RCC) is a major neoplasm with high incidence in western countries. Tumors are heterogeneous and are composed of differentiated cancer cells, stromal cells, and cancer stem cells (CSCs). CSCs possess two main properties: self-renewal and proliferation. Additionally, they can generate new tumors once transplanted into immunodeficient mice. Several approaches have been described to identify them, through the expression of cell markers, functional assays, or a combination of both. As CSCs are involved in the resistance mechanisms to radio- and chemotherapies, several new strategies have been proposed to directly target CSCs in RCC. One approach drives CSCs to differentiate into cancer cells sensitive to conventional treatments, while the other proposes to eradicate them selectively. A series of innovative therapies aiming at eliminating CSCs have been designed to treat other types of cancer and have not been experimented with on RCC yet, but they reveal themselves to be promising. In conclusion, CSCs are an important player in carcinogenesis and represent a valid target for therapy in RCC patients.http://dx.doi.org/10.1155/2016/8342625 |
| spellingShingle | Anna Julie Peired Alessandro Sisti Paola Romagnani Renal Cancer Stem Cells: Characterization and Targeted Therapies Stem Cells International |
| title | Renal Cancer Stem Cells: Characterization and Targeted Therapies |
| title_full | Renal Cancer Stem Cells: Characterization and Targeted Therapies |
| title_fullStr | Renal Cancer Stem Cells: Characterization and Targeted Therapies |
| title_full_unstemmed | Renal Cancer Stem Cells: Characterization and Targeted Therapies |
| title_short | Renal Cancer Stem Cells: Characterization and Targeted Therapies |
| title_sort | renal cancer stem cells characterization and targeted therapies |
| url | http://dx.doi.org/10.1155/2016/8342625 |
| work_keys_str_mv | AT annajuliepeired renalcancerstemcellscharacterizationandtargetedtherapies AT alessandrosisti renalcancerstemcellscharacterizationandtargetedtherapies AT paolaromagnani renalcancerstemcellscharacterizationandtargetedtherapies |