Case of a CD3 Negative Hepatosplenic T-Cell Lymphoma: Diagnostic and Therapeutic Challenges
Hepatosplenic T-cell lymphomas (TCLs) are a rare, aggressive subset of TCLs, accounting for less than 5% of all peripheral T-cell and natural killer (NK) cell lymphomas. We report the case of a CD3 negative hepatosplenic T-cell lymphoma in a 42-year-old female, who presented with left-sided abdomina...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/5315086 |
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| _version_ | 1832548416251494400 |
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| author | Laura Alder Scott Graupner Guanhua Lai Victor Yazbeck |
| author_facet | Laura Alder Scott Graupner Guanhua Lai Victor Yazbeck |
| author_sort | Laura Alder |
| collection | DOAJ |
| description | Hepatosplenic T-cell lymphomas (TCLs) are a rare, aggressive subset of TCLs, accounting for less than 5% of all peripheral T-cell and natural killer (NK) cell lymphomas. We report the case of a CD3 negative hepatosplenic T-cell lymphoma in a 42-year-old female, who presented with left-sided abdominal pain. She underwent a liver biopsy that showed marked abnormal sinusoidal lymphoid infiltration. PET scan revealed increased splenic and pharyngeal lymph node uptake. Immunophenotype was remarkable for negative CD3, gamma delta T-cell receptor, and alpha beta-T-cell receptor expression. She received 6 cycles of DA-EPOCH, had primary refractory disease and then underwent palliative splenectomy secondary to painful necrosis. Then, she was started on pralatrexate as a single agent and then in combination with romidepsin as a potential bridge to an allogeneic stem cell transplantation from her sibling. |
| format | Article |
| id | doaj-art-9fcecf4463a7468aa38938e73712752d |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-9fcecf4463a7468aa38938e73712752d2025-02-03T06:14:13ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/53150865315086Case of a CD3 Negative Hepatosplenic T-Cell Lymphoma: Diagnostic and Therapeutic ChallengesLaura Alder0Scott Graupner1Guanhua Lai2Victor Yazbeck3Department of Medicine, VCU Health, 1201 E Marshall St, Richmond, VA 23298, USADepartment of Hematology Oncology, Massey Cancer Center, VCU Health, 401 College St, Richmond, VA 23298, USADepartment of Pathology, VCU Health, 1201 E Marshall St, Richmond, VA 23298, USADepartment of Hematology Oncology, Massey Cancer Center, VCU Health, 401 College St, Richmond, VA 23298, USAHepatosplenic T-cell lymphomas (TCLs) are a rare, aggressive subset of TCLs, accounting for less than 5% of all peripheral T-cell and natural killer (NK) cell lymphomas. We report the case of a CD3 negative hepatosplenic T-cell lymphoma in a 42-year-old female, who presented with left-sided abdominal pain. She underwent a liver biopsy that showed marked abnormal sinusoidal lymphoid infiltration. PET scan revealed increased splenic and pharyngeal lymph node uptake. Immunophenotype was remarkable for negative CD3, gamma delta T-cell receptor, and alpha beta-T-cell receptor expression. She received 6 cycles of DA-EPOCH, had primary refractory disease and then underwent palliative splenectomy secondary to painful necrosis. Then, she was started on pralatrexate as a single agent and then in combination with romidepsin as a potential bridge to an allogeneic stem cell transplantation from her sibling.http://dx.doi.org/10.1155/2019/5315086 |
| spellingShingle | Laura Alder Scott Graupner Guanhua Lai Victor Yazbeck Case of a CD3 Negative Hepatosplenic T-Cell Lymphoma: Diagnostic and Therapeutic Challenges Case Reports in Hematology |
| title | Case of a CD3 Negative Hepatosplenic T-Cell Lymphoma: Diagnostic and Therapeutic Challenges |
| title_full | Case of a CD3 Negative Hepatosplenic T-Cell Lymphoma: Diagnostic and Therapeutic Challenges |
| title_fullStr | Case of a CD3 Negative Hepatosplenic T-Cell Lymphoma: Diagnostic and Therapeutic Challenges |
| title_full_unstemmed | Case of a CD3 Negative Hepatosplenic T-Cell Lymphoma: Diagnostic and Therapeutic Challenges |
| title_short | Case of a CD3 Negative Hepatosplenic T-Cell Lymphoma: Diagnostic and Therapeutic Challenges |
| title_sort | case of a cd3 negative hepatosplenic t cell lymphoma diagnostic and therapeutic challenges |
| url | http://dx.doi.org/10.1155/2019/5315086 |
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