LPS-induced serum TNF production and lethality in mice: effect of L-carnitine and some acyl-derivatives
The effect of L-carnitine and some of its acyl derivatives on serum TNF production and lethality in a murine experimental endotoxin shock model was investigated. In some instances, serum IL-6 production was also evaluated. In this experimental model, C57BL/6 mice received 30 mg/kg LPS (E. cell 055:B...
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| Format: | Article |
| Language: | English |
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Wiley
1993-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935193000754 |
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| author | Vito Ruggiero Claudio M. D'Urso Claudio Albertoni Silvia Campo Piero Foresta Edoardo Arrigoni Martelli |
| author_facet | Vito Ruggiero Claudio M. D'Urso Claudio Albertoni Silvia Campo Piero Foresta Edoardo Arrigoni Martelli |
| author_sort | Vito Ruggiero |
| collection | DOAJ |
| description | The effect of L-carnitine and some of its acyl derivatives on serum TNF production and lethality in a murine experimental endotoxin shock model was investigated. In some instances, serum IL-6 production was also evaluated. In this experimental model, C57BL/6 mice received 30 mg/kg LPS (E. cell 055:B5) injected intraperitoneally, while L-carnitine and its derivatives were administered according to different schedules. Serum levels of TNF and IL-6 were evaluated 1 h following LPS injection. The treated animals were also monitored daily for differences in body temperature, feeding, and survival for 10 days after LPS injection. Although some derivatives were able to significantly affect TNF production, the marked decrease in serum TNF levels of LPS-treated mice was not paralleled by a substantial increase in survival. |
| format | Article |
| id | doaj-art-9fc4d291e602461793b214edd5be5cf1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1993-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9fc4d291e602461793b214edd5be5cf12025-02-03T01:03:39ZengWileyMediators of Inflammation0962-93511466-18611993-01-0127S43S5010.1155/S0962935193000754LPS-induced serum TNF production and lethality in mice: effect of L-carnitine and some acyl-derivativesVito Ruggiero0Claudio M. D'Urso1Claudio Albertoni2Silvia Campo3Piero Foresta4Edoardo Arrigoni Martelli5Sigma Tau Ind. Farm., Riun. SpA, Research and Development, Department of Microbiology and Immunology, Via Pontina Km. 30, Pomezia 400, 00040, ItalySigma Tau Ind. Farm., Riun. SpA, Research and Development, Department of Microbiology and Immunology, Via Pontina Km. 30, Pomezia 400, 00040, ItalySigma Tau Ind. Farm., Riun. SpA, Research and Development, Department of Microbiology and Immunology, Via Pontina Km. 30, Pomezia 400, 00040, ItalySigma Tau Ind. Farm., Riun. SpA, Research and Development, Department of Microbiology and Immunology, Via Pontina Km. 30, Pomezia 400, 00040, ItalySigma Tau Ind. Farm., Riun. SpA, Research and Development, Department of Microbiology and Immunology, Via Pontina Km. 30, Pomezia 400, 00040, ItalySigma Tau Ind. Farm., Riun. SpA, Research and Development, Department of Microbiology and Immunology, Via Pontina Km. 30, Pomezia 400, 00040, ItalyThe effect of L-carnitine and some of its acyl derivatives on serum TNF production and lethality in a murine experimental endotoxin shock model was investigated. In some instances, serum IL-6 production was also evaluated. In this experimental model, C57BL/6 mice received 30 mg/kg LPS (E. cell 055:B5) injected intraperitoneally, while L-carnitine and its derivatives were administered according to different schedules. Serum levels of TNF and IL-6 were evaluated 1 h following LPS injection. The treated animals were also monitored daily for differences in body temperature, feeding, and survival for 10 days after LPS injection. Although some derivatives were able to significantly affect TNF production, the marked decrease in serum TNF levels of LPS-treated mice was not paralleled by a substantial increase in survival.http://dx.doi.org/10.1155/S0962935193000754 |
| spellingShingle | Vito Ruggiero Claudio M. D'Urso Claudio Albertoni Silvia Campo Piero Foresta Edoardo Arrigoni Martelli LPS-induced serum TNF production and lethality in mice: effect of L-carnitine and some acyl-derivatives Mediators of Inflammation |
| title | LPS-induced serum TNF production and lethality in mice: effect of L-carnitine and some acyl-derivatives |
| title_full | LPS-induced serum TNF production and lethality in mice: effect of L-carnitine and some acyl-derivatives |
| title_fullStr | LPS-induced serum TNF production and lethality in mice: effect of L-carnitine and some acyl-derivatives |
| title_full_unstemmed | LPS-induced serum TNF production and lethality in mice: effect of L-carnitine and some acyl-derivatives |
| title_short | LPS-induced serum TNF production and lethality in mice: effect of L-carnitine and some acyl-derivatives |
| title_sort | lps induced serum tnf production and lethality in mice effect of l carnitine and some acyl derivatives |
| url | http://dx.doi.org/10.1155/S0962935193000754 |
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