Hearing Loss due to Infiltration of the Tympanic Membrane by Chronic Lymphocytic Leukemia
Central nervous system (CNS) involvement by chronic lymphocytic leukemia (CLL) can present with dramatic neurologic findings or can be quite subtle, discovered only at the time of autopsy. We describe a case of CLL in a patient who presented initially with hearing loss and was ultimately found to ha...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/589718 |
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| author | Jonathon B. Cohen Robert Cavaliere John C. Byrd Leslie A. Andritsos |
| author_facet | Jonathon B. Cohen Robert Cavaliere John C. Byrd Leslie A. Andritsos |
| author_sort | Jonathon B. Cohen |
| collection | DOAJ |
| description | Central nervous system (CNS) involvement by chronic lymphocytic leukemia (CLL) can present with dramatic neurologic findings or can be quite subtle, discovered only at the time of autopsy. We describe a case of CLL in a patient who presented initially with hearing loss and was ultimately found to have involvement of the tympanic membrane. She noted improvement of her hearing after induction therapy but was not aware at the time of the involvement of her CNS with CLL. Upon worsening of hearing at the time of relapse, she was evaluated by imaging and CSF analysis as well as biopsy of the tympanic membrane, and involvement of the CNS was confirmed. She has received CNS-directed therapy with intrathecal liposomal cytarabine and intravenous CNS-directed therapy and has noted improved hearing and resolution of her imaging and CSF findings. This is the first reported case of tympanic membrane involvement with CLL and describes potentially effective methods for managing this challenging complication. |
| format | Article |
| id | doaj-art-9fbee4b84fe647d6a5d495b2ef4b99e3 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-9fbee4b84fe647d6a5d495b2ef4b99e32025-02-03T01:33:12ZengWileyCase Reports in Hematology2090-65602090-65792012-01-01201210.1155/2012/589718589718Hearing Loss due to Infiltration of the Tympanic Membrane by Chronic Lymphocytic LeukemiaJonathon B. Cohen0Robert Cavaliere1John C. Byrd2Leslie A. Andritsos3Division of Hematology, The Arthur G. James Comprehensive Cancer Center and The Ohio State University, 320 W 10th Avenue, B354 Starling Loving Hall, Columbus, OH 43210, USADepartment of Neurosurgery, The Arthur G. James Comprehensive Cancer Center and The Ohio State University, Columbus, OH 43210, USADivision of Hematology, The Arthur G. James Comprehensive Cancer Center and The Ohio State University, 320 W 10th Avenue, B354 Starling Loving Hall, Columbus, OH 43210, USADivision of Hematology, The Arthur G. James Comprehensive Cancer Center and The Ohio State University, 320 W 10th Avenue, B354 Starling Loving Hall, Columbus, OH 43210, USACentral nervous system (CNS) involvement by chronic lymphocytic leukemia (CLL) can present with dramatic neurologic findings or can be quite subtle, discovered only at the time of autopsy. We describe a case of CLL in a patient who presented initially with hearing loss and was ultimately found to have involvement of the tympanic membrane. She noted improvement of her hearing after induction therapy but was not aware at the time of the involvement of her CNS with CLL. Upon worsening of hearing at the time of relapse, she was evaluated by imaging and CSF analysis as well as biopsy of the tympanic membrane, and involvement of the CNS was confirmed. She has received CNS-directed therapy with intrathecal liposomal cytarabine and intravenous CNS-directed therapy and has noted improved hearing and resolution of her imaging and CSF findings. This is the first reported case of tympanic membrane involvement with CLL and describes potentially effective methods for managing this challenging complication.http://dx.doi.org/10.1155/2012/589718 |
| spellingShingle | Jonathon B. Cohen Robert Cavaliere John C. Byrd Leslie A. Andritsos Hearing Loss due to Infiltration of the Tympanic Membrane by Chronic Lymphocytic Leukemia Case Reports in Hematology |
| title | Hearing Loss due to Infiltration of the Tympanic Membrane by Chronic Lymphocytic Leukemia |
| title_full | Hearing Loss due to Infiltration of the Tympanic Membrane by Chronic Lymphocytic Leukemia |
| title_fullStr | Hearing Loss due to Infiltration of the Tympanic Membrane by Chronic Lymphocytic Leukemia |
| title_full_unstemmed | Hearing Loss due to Infiltration of the Tympanic Membrane by Chronic Lymphocytic Leukemia |
| title_short | Hearing Loss due to Infiltration of the Tympanic Membrane by Chronic Lymphocytic Leukemia |
| title_sort | hearing loss due to infiltration of the tympanic membrane by chronic lymphocytic leukemia |
| url | http://dx.doi.org/10.1155/2012/589718 |
| work_keys_str_mv | AT jonathonbcohen hearinglossduetoinfiltrationofthetympanicmembranebychroniclymphocyticleukemia AT robertcavaliere hearinglossduetoinfiltrationofthetympanicmembranebychroniclymphocyticleukemia AT johncbyrd hearinglossduetoinfiltrationofthetympanicmembranebychroniclymphocyticleukemia AT leslieaandritsos hearinglossduetoinfiltrationofthetympanicmembranebychroniclymphocyticleukemia |