Copper sensing transcription factor ArsR2 regulates VjbR to sustain virulence in Brucella abortus
Brucellosis, caused by the intracellular pathogen Brucella, is a major zoonotic infection that promotes reproductive disease in domestic animals and chronic debilitating conditions in humans. The ArsR family of transcriptional regulators plays key roles in diverse cellular processes, including metal...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2024.2406274 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850262243970646016 |
|---|---|
| author | Feijie Zhi Kemeng Liu Hao Geng Mengru Su Jian Xu Lei Fu Ke Ma Pengcheng Gao Lvfeng Yuan YueFeng Chu |
| author_facet | Feijie Zhi Kemeng Liu Hao Geng Mengru Su Jian Xu Lei Fu Ke Ma Pengcheng Gao Lvfeng Yuan YueFeng Chu |
| author_sort | Feijie Zhi |
| collection | DOAJ |
| description | Brucellosis, caused by the intracellular pathogen Brucella, is a major zoonotic infection that promotes reproductive disease in domestic animals and chronic debilitating conditions in humans. The ArsR family of transcriptional regulators plays key roles in diverse cellular processes, including metal ion homeostasis, responding to adverse conditions, and virulence. However, little is known about the function of ArsR family members in Brucella. Here, we identified ArsR2 as a nonclassical member of the family that lacks autoregulatory function, but which nevertheless plays a vital role in maintaining copper homeostasis in B. abortus. ArsR2 is a global regulator of 241 genes, including those involved in the VirB type IV secretion system (T4SS). Significantly, ArsR2 regulates T4SS production in B. abortus by targeting VjbR which encodes a LuxR-type family transcriptional regulator. Moreover, copper modulates transcriptional activity of ArsR2, but not of VjbR. Furthermore, deletion of arsR2 attenuated virulence in a mouse model. Collectively, these findings enhance understanding of the mechanism by which ArsR proteins regulate virulence gene expression in pathogenic Brucella species. |
| format | Article |
| id | doaj-art-9fb962bdfd0a480ea3d05e8e6211e886 |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-9fb962bdfd0a480ea3d05e8e6211e8862025-08-20T01:55:12ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512024-12-0113110.1080/22221751.2024.2406274Copper sensing transcription factor ArsR2 regulates VjbR to sustain virulence in Brucella abortusFeijie Zhi0Kemeng Liu1Hao Geng2Mengru Su3Jian Xu4Lei Fu5Ke Ma6Pengcheng Gao7Lvfeng Yuan8YueFeng Chu9State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, People’s Republic of ChinaState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou Veterinary Research Institute, Lanzhou University, Chinese Academy of Agricultural Sciences, Lanzhou, People’s Republic of ChinaBrucellosis, caused by the intracellular pathogen Brucella, is a major zoonotic infection that promotes reproductive disease in domestic animals and chronic debilitating conditions in humans. The ArsR family of transcriptional regulators plays key roles in diverse cellular processes, including metal ion homeostasis, responding to adverse conditions, and virulence. However, little is known about the function of ArsR family members in Brucella. Here, we identified ArsR2 as a nonclassical member of the family that lacks autoregulatory function, but which nevertheless plays a vital role in maintaining copper homeostasis in B. abortus. ArsR2 is a global regulator of 241 genes, including those involved in the VirB type IV secretion system (T4SS). Significantly, ArsR2 regulates T4SS production in B. abortus by targeting VjbR which encodes a LuxR-type family transcriptional regulator. Moreover, copper modulates transcriptional activity of ArsR2, but not of VjbR. Furthermore, deletion of arsR2 attenuated virulence in a mouse model. Collectively, these findings enhance understanding of the mechanism by which ArsR proteins regulate virulence gene expression in pathogenic Brucella species.https://www.tandfonline.com/doi/10.1080/22221751.2024.2406274BrucellaArsRT4SSVjbRvirulence |
| spellingShingle | Feijie Zhi Kemeng Liu Hao Geng Mengru Su Jian Xu Lei Fu Ke Ma Pengcheng Gao Lvfeng Yuan YueFeng Chu Copper sensing transcription factor ArsR2 regulates VjbR to sustain virulence in Brucella abortus Emerging Microbes and Infections Brucella ArsR T4SS VjbR virulence |
| title | Copper sensing transcription factor ArsR2 regulates VjbR to sustain virulence in Brucella abortus |
| title_full | Copper sensing transcription factor ArsR2 regulates VjbR to sustain virulence in Brucella abortus |
| title_fullStr | Copper sensing transcription factor ArsR2 regulates VjbR to sustain virulence in Brucella abortus |
| title_full_unstemmed | Copper sensing transcription factor ArsR2 regulates VjbR to sustain virulence in Brucella abortus |
| title_short | Copper sensing transcription factor ArsR2 regulates VjbR to sustain virulence in Brucella abortus |
| title_sort | copper sensing transcription factor arsr2 regulates vjbr to sustain virulence in brucella abortus |
| topic | Brucella ArsR T4SS VjbR virulence |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2024.2406274 |
| work_keys_str_mv | AT feijiezhi coppersensingtranscriptionfactorarsr2regulatesvjbrtosustainvirulenceinbrucellaabortus AT kemengliu coppersensingtranscriptionfactorarsr2regulatesvjbrtosustainvirulenceinbrucellaabortus AT haogeng coppersensingtranscriptionfactorarsr2regulatesvjbrtosustainvirulenceinbrucellaabortus AT mengrusu coppersensingtranscriptionfactorarsr2regulatesvjbrtosustainvirulenceinbrucellaabortus AT jianxu coppersensingtranscriptionfactorarsr2regulatesvjbrtosustainvirulenceinbrucellaabortus AT leifu coppersensingtranscriptionfactorarsr2regulatesvjbrtosustainvirulenceinbrucellaabortus AT kema coppersensingtranscriptionfactorarsr2regulatesvjbrtosustainvirulenceinbrucellaabortus AT pengchenggao coppersensingtranscriptionfactorarsr2regulatesvjbrtosustainvirulenceinbrucellaabortus AT lvfengyuan coppersensingtranscriptionfactorarsr2regulatesvjbrtosustainvirulenceinbrucellaabortus AT yuefengchu coppersensingtranscriptionfactorarsr2regulatesvjbrtosustainvirulenceinbrucellaabortus |